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• W2034629146 abstract "Microwave-assisted synthesis and investigation of antitubercular profile of new 2-(trifluoromethyl)-6-arylimidazo[2,1- b ][1,3,4]-thiadiazole derivatives are described. The increase in the prevalence of multi drug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis case demonstrates the urgent need of discovering new promising compounds with antimycobacterial activity. As part of our research program and with a aim of identifying new antitubercular drug candidates, a new class of 2-(trifluoromethyl)-6-arylimidazo[2,1- b ][1,3,4]thiadiazole derivatives has been synthesized by both conventional as well as microwave assisted method and evaluated for their in vitro antitubercular activity against M . tuberculosis H 37 Rv. Moreover, various drug-likeness properties of new compounds were predicted. Seven compounds from the series exhibited good activity with MIC in range 3.12–1.56 μg/ml. The present study suggests that compounds 6b , 6c , 6d , 6e and 6f may serve as promising lead scaffolds for further generation of new anti-TB agents." @default.
• W2034629146 created "2016-06-24" @default.
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• W2034629146 date "2012-03-01" @default.
• W2034629146 modified "2023-09-29" @default.
• W2034629146 title "Novel imidazo[2,1-b][1,3,4]thiadiazole carrying rhodanine-3-acetic acid as potential antitubercular agents" @default.
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• W2034629146 doi "https://doi.org/10.1016/j.bmcl.2012.01.052" @default.
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