FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034630124> ?p ?o ?g. }

• W2034630124 endingPage "370" @default.
• W2034630124 startingPage "362" @default.
• W2034630124 abstract "In Brief Introduction: Fungal endophthalmitis is a rare but sight-threatening disease. Despite an expanding range of fungal pathogens, there are only few therapeutic agents for its treatment available. Voriconazole is a second-generation synthetic triazole with a broad action against yeasts and molds. The current study investigates the safety of Voriconazole for intravitreal application in a cell culture model. Methods: Primary human retinal pigment epithelium cells (RPE) and primary human optic nerve head astrocytes were treated with concentrations of Voriconazole ranging from 25 μg/mL to 10 mg/mL. Possible toxic effects and IC50 were evaluated after 24 hours and under conditions of oxidative stress. By treating the RPE cell lines with tumor-necrosisfactor alpha (TNF-α), lipopolysaccharides (LPS), and interleukin-6 (IL-6) the effects of Voriconazole on cellular viability under conditions of inflammation were investigated. Toxicity was evaluated by colorimetric measuring the inhibition of RPE cell proliferation (MTT). Additionally cell viability was quantified by a microscopic live–dead-assay. Results: Concentrations <250 μg/mL Voriconazole had no influence neither on RPE nor on optic nerve head astrocytes cell proliferation and cell viability when administered for 24 hours and under oxidative stress. When preincubated with tumor-necrosis-factor alpha, lipopolysaccharides and interleukin-6 for 24 hours and subsequently treated with Voriconazole at concentrations up to 250 μg/mL for 24 hours no significant decrease in proliferation and viability was observed. Conclusions: This study showed that no significant toxicity existed for Voriconazole in vitro on primary RPE and optic nerve head astrocytes when administered in therapeutic concentrations up to 250 μg/mL. This study showed that no significant toxicity existed for Voriconazole in vitro on primary RPE and optic nerve head astrocytes when administered in therapeutic concentrations up to 250 μg/mL." @default.
• W2034630124 created "2016-06-24" @default.
• W2034630124 creator A5037807436 @default.
• W2034630124 creator A5038996603 @default.
• W2034630124 creator A5051825660 @default.
• W2034630124 creator A5056974211 @default.
• W2034630124 date "2009-03-01" @default.
• W2034630124 modified "2023-10-16" @default.
• W2034630124 title "INTRAVITREAL VORICONAZOLE" @default.
• W2034630124 cites W1415091912 @default.
• W2034630124 cites W1502509101 @default.
• W2034630124 cites W1565636659 @default.
• W2034630124 cites W1577160752 @default.
• W2034630124 cites W1587054336 @default.
• W2034630124 cites W16002870 @default.
• W2034630124 cites W1968527595 @default.
• W2034630124 cites W1968586271 @default.
• W2034630124 cites W1969690165 @default.
• W2034630124 cites W1971834604 @default.
• W2034630124 cites W1979584213 @default.
• W2034630124 cites W1981312626 @default.
• W2034630124 cites W1982026089 @default.
• W2034630124 cites W1983034392 @default.
• W2034630124 cites W1985104966 @default.
• W2034630124 cites W1998840608 @default.
• W2034630124 cites W1998901848 @default.
• W2034630124 cites W2012532771 @default.
• W2034630124 cites W2019267171 @default.
• W2034630124 cites W2023047656 @default.
• W2034630124 cites W2030708705 @default.
• W2034630124 cites W2030851008 @default.
• W2034630124 cites W2035626868 @default.
• W2034630124 cites W2040934856 @default.
• W2034630124 cites W2049686946 @default.
• W2034630124 cites W2062329228 @default.
• W2034630124 cites W2070885165 @default.
• W2034630124 cites W2072733345 @default.
• W2034630124 cites W2074503324 @default.
• W2034630124 cites W2079223667 @default.
• W2034630124 cites W2083654319 @default.
• W2034630124 cites W2085153697 @default.
• W2034630124 cites W2090464001 @default.
• W2034630124 cites W2098256719 @default.
• W2034630124 cites W2105376278 @default.
• W2034630124 cites W2114918609 @default.
• W2034630124 cites W2117680151 @default.
• W2034630124 cites W2121213050 @default.
• W2034630124 cites W2126617328 @default.
• W2034630124 cites W2130694284 @default.
• W2034630124 cites W2134130150 @default.
• W2034630124 cites W2134219075 @default.
• W2034630124 cites W2137963716 @default.
• W2034630124 cites W2144149632 @default.
• W2034630124 cites W2156275638 @default.
• W2034630124 cites W2158019501 @default.
• W2034630124 cites W2164996340 @default.
• W2034630124 cites W47884864 @default.
• W2034630124 cites W91650790 @default.
• W2034630124 doi "https://doi.org/10.1097/iae.0b013e31818d4b9b" @default.
• W2034630124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18997637" @default.
• W2034630124 hasPublicationYear "2009" @default.
• W2034630124 type Work @default.
• W2034630124 sameAs 2034630124 @default.
• W2034630124 citedByCount "44" @default.
• W2034630124 countsByYear W20346301242012 @default.
• W2034630124 countsByYear W20346301242013 @default.
• W2034630124 countsByYear W20346301242014 @default.
• W2034630124 countsByYear W20346301242015 @default.
• W2034630124 countsByYear W20346301242016 @default.
• W2034630124 countsByYear W20346301242017 @default.
• W2034630124 countsByYear W20346301242018 @default.
• W2034630124 countsByYear W20346301242019 @default.
• W2034630124 countsByYear W20346301242020 @default.
• W2034630124 countsByYear W20346301242022 @default.
• W2034630124 crossrefType "journal-article" @default.
• W2034630124 hasAuthorship W2034630124A5037807436 @default.
• W2034630124 hasAuthorship W2034630124A5038996603 @default.
• W2034630124 hasAuthorship W2034630124A5051825660 @default.
• W2034630124 hasAuthorship W2034630124A5056974211 @default.
• W2034630124 hasConcept C126322002 @default.
• W2034630124 hasConcept C1491633281 @default.
• W2034630124 hasConcept C17991360 @default.
• W2034630124 hasConcept C185592680 @default.
• W2034630124 hasConcept C203014093 @default.
• W2034630124 hasConcept C2779548794 @default.
• W2034630124 hasConcept C2780690907 @default.
• W2034630124 hasConcept C2780783641 @default.
• W2034630124 hasConcept C29730261 @default.
• W2034630124 hasConcept C53227056 @default.
• W2034630124 hasConcept C55493867 @default.
• W2034630124 hasConcept C62112901 @default.
• W2034630124 hasConcept C71924100 @default.
• W2034630124 hasConcept C86803240 @default.
• W2034630124 hasConcept C89423630 @default.
• W2034630124 hasConcept C98274493 @default.
• W2034630124 hasConceptScore W2034630124C126322002 @default.
• W2034630124 hasConceptScore W2034630124C1491633281 @default.
• W2034630124 hasConceptScore W2034630124C17991360 @default.

• next