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- W2034631721 abstract "Background. Long-term treatment with cyclosporine A (CsA) causes tubulointerstitial inflammation and fibrosis in the kidney. To define the role of lymphocytes in this process, the novel lymphocyte-specific inhibitor FTY720 was administered to rats with experimental model of chronic CsA nephropathy. Methods. Sprague-Dawley rats were treated daily for 4 weeks with CsA (7.5 mg/kg), or both CsA and FTY720 (0.125 mg/kg). The effects of FTY720 on CsA-induced renal injury were evaluated using renal function tests and histopathology, and the expression of mediators of CsA-induced renal injury (osteopontin, transforming growth factor–beta1 [TGF-β1], βig-h3, and angiotensin II). Results. FTY720 treatment significantly decreased T-lymphocyte accumulation in kidneys compared with CsA treatment alone. FTY720 treatment improved not only CsA-induced renal dysfunction but also renal histopathology, demonstrated by decreased macrophage infiltration and interstitial fibrosis. Increased osteopontin, TGF-β1, βig-h3, and angiotensin II expression in CsA-treated rat kidneys were decreased with FTY720 treatment. Conclusions. FTY720 treatment prevents CsA-induced renal injury." @default.
- W2034631721 created "2016-06-24" @default.
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- W2034631721 date "2005-11-01" @default.
- W2034631721 modified "2023-09-25" @default.
- W2034631721 title "Effect of FTY720 on Chronic Cyclosporine Nephropathy in Rats" @default.
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- W2034631721 doi "https://doi.org/10.1097/01.tp.0000189709.21474.33" @default.
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