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• W2034632349 abstract "Inbred mouse strains differ in their preferences for sweeteners, due in part to variations in their T1R3 sweet taste receptor. Recent studies of sweet sensitive C57BL/6J (B6) and subsensitive 129P3/J (129) mice indicate that experiential and post-oral effects of sugar substantially modify sweetener preference. In fact, the strain difference in sucrose preference disappeared after the mice were given 23 h/day tests with sucrose at ascending concentrations (0.5–32%). Intragastric infusions of sucrose (16%) also conditioned increased preference for and absolute intake of flavored sweet solutions in B6 and 129 mice. An operant analysis of sweetener appetite revealed, unexpectedly, that sugar-experienced 129 mice respond more vigorously than B6 mice for 16% sucrose rewards. These findings indicate that experiential and nutritional factors can, to some degree, override genetic differences in peripheral taste sensitivity in determining food appetite." @default.
• W2034632349 created "2016-06-24" @default.
• W2034632349 creator A5032957137 @default.
• W2034632349 date "2006-11-01" @default.
• W2034632349 modified "2023-09-23" @default.
• W2034632349 title "Oral, post-oral and genetic interactions in sweet appetite" @default.
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• W2034632349 doi "https://doi.org/10.1016/j.physbeh.2006.03.021" @default.
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