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- W2034632748 abstract "Because of its cytosolic localization, Listeria monocytogenes (LM) has long been considered an attractive tool for delivering tumor-associated antigens (TAA) antigens in vivoto combat cancer. LM directly infects antigen-presenting cells (APC) such as monocytes, macrophages and dendritic cells (DC), thereby delivering the TAA into their cytoplasm, resulting in processing, and presentation of the antigen to the immune system. This activates adaptive and innate immune responses to the TAA, mediating tumor cell cytolysis. Recently we discovered additional pathways by which Listeria can be harnessedto induce tumor cell death, which suggest new directions in the development of vaccines or therapies against cancer. In one approach, we have used Listeria to induce immune responses that destroy tumor vasculature. Another new pathway involves selective infection of cancer cells with Listeria, followed by tumor cell death through the production of high levels of reactive oxygen species (ROS) and through Listeria-specific cytotoxic T lymphocytes (CTL). This review will focus on the most recent studies on the multiple pathways of LM and how they can be harnessed in the battle against cancer." @default.
- W2034632748 created "2016-06-24" @default.
- W2034632748 creator A5010825732 @default.
- W2034632748 creator A5091812025 @default.
- W2034632748 date "2010-02-15" @default.
- W2034632748 modified "2023-09-25" @default.
- W2034632748 title "Harnessing Listeria monocytogenes to target tumors" @default.
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- W2034632748 doi "https://doi.org/10.4161/cbt.9.4.11216" @default.
- W2034632748 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4888915" @default.
- W2034632748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20139702" @default.
- W2034632748 hasPublicationYear "2010" @default.
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