FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034632827> ?p ?o ?g. }

• W2034632827 endingPage "296" @default.
• W2034632827 startingPage "291" @default.
• W2034632827 abstract "Adenylyl cyclase (AC) activity was studied in post mortem hippocampus and cerebellum from eight patients with Alzheimer's disease/senile dementia of the Alzheimer type (AD/SDAT) and seven non-demented control patients. AC was stimulated via stimulatory guanine nucleotide binding proteins (Gs) using guanosine triphosphate (GTP) and GppNHp (both 10−4M) or directly with either forskolin (10−4M) or Mn2+ (10−2M). Inhibition of AC via A1-receptors was performed with N6-cyclohexyladenosine (CHA) under basal conditions and in the presence of forskolin (10−5M). In both brain regions AC activity was significantly reduced in AD/SDAT when compared to controls. Under basal conditions and after stimulation via Gs mean reduction in hippocampus and cerebellum was 47.7% and 58.2%, respectively. The reduction was less pronounced after direct activation of the AC, amounting to 21.8% in hippocampus and 28.1% in cerebellum. CHA inhibited basal and forskolin-stimulated AC concentration-dependently by about 20% (basal) and 30% (forskolin). Inhibition by CHA was similar in hippocampus and cerebellum and tended to be more pronounced in AD/SDAT than in controls. Since the reduction of AC activity in AD/SDAT is greater after stimulation via Gs than after direct activation of the catalytic subunit, we suggest that both Gs and the catalytic subunit seem to be impaired. The fact that CHA-mediated inhibition of AC is not significantly different in AD/SDAT and controls, indicates that in contrast to Gs-, inhibitory G-proteins (Gi) coupling to AC remains intact in Alzheimer's disease." @default.
• W2034632827 created "2016-06-24" @default.
• W2034632827 creator A5011795712 @default.
• W2034632827 creator A5014868745 @default.
• W2034632827 creator A5059731153 @default.
• W2034632827 creator A5063579369 @default.
• W2034632827 creator A5090435790 @default.
• W2034632827 date "1994-05-01" @default.
• W2034632827 modified "2023-09-30" @default.
• W2034632827 title "Adenylyl cyclase activity in Alzheimer's disease brain: stimulatory and inhibitory signal transduction pathways are differently affected" @default.
• W2034632827 cites W17693006 @default.
• W2034632827 cites W1775749144 @default.
• W2034632827 cites W1978789495 @default.
• W2034632827 cites W1978798092 @default.
• W2034632827 cites W1991938120 @default.
• W2034632827 cites W2005598989 @default.
• W2034632827 cites W2015647437 @default.
• W2034632827 cites W2016560676 @default.
• W2034632827 cites W2026375298 @default.
• W2034632827 cites W2042244486 @default.
• W2034632827 cites W2046341498 @default.
• W2034632827 cites W2052742260 @default.
• W2034632827 cites W2057928799 @default.
• W2034632827 cites W2065588115 @default.
• W2034632827 cites W2065708060 @default.
• W2034632827 cites W2065962764 @default.
• W2034632827 cites W2066389071 @default.
• W2034632827 cites W2076272666 @default.
• W2034632827 cites W2076679157 @default.
• W2034632827 cites W2077264392 @default.
• W2034632827 cites W2092300550 @default.
• W2034632827 cites W2094701828 @default.
• W2034632827 cites W2104227586 @default.
• W2034632827 cites W2114776686 @default.
• W2034632827 cites W2126974689 @default.
• W2034632827 doi "https://doi.org/10.1016/0006-8993(94)91692-6" @default.
• W2034632827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7914148" @default.
• W2034632827 hasPublicationYear "1994" @default.
• W2034632827 type Work @default.
• W2034632827 sameAs 2034632827 @default.
• W2034632827 citedByCount "52" @default.
• W2034632827 countsByYear W20346328272016 @default.
• W2034632827 countsByYear W20346328272017 @default.
• W2034632827 countsByYear W20346328272018 @default.
• W2034632827 countsByYear W20346328272019 @default.
• W2034632827 countsByYear W20346328272020 @default.
• W2034632827 countsByYear W20346328272021 @default.
• W2034632827 crossrefType "journal-article" @default.
• W2034632827 hasAuthorship W2034632827A5011795712 @default.
• W2034632827 hasAuthorship W2034632827A5014868745 @default.
• W2034632827 hasAuthorship W2034632827A5059731153 @default.
• W2034632827 hasAuthorship W2034632827A5063579369 @default.
• W2034632827 hasAuthorship W2034632827A5090435790 @default.
• W2034632827 hasConcept C118716 @default.
• W2034632827 hasConcept C126322002 @default.
• W2034632827 hasConcept C134018914 @default.
• W2034632827 hasConcept C170493617 @default.
• W2034632827 hasConcept C181199279 @default.
• W2034632827 hasConcept C185592680 @default.
• W2034632827 hasConcept C24998067 @default.
• W2034632827 hasConcept C2777995097 @default.
• W2034632827 hasConcept C2779134260 @default.
• W2034632827 hasConcept C2779178603 @default.
• W2034632827 hasConcept C2779276759 @default.
• W2034632827 hasConcept C2779652256 @default.
• W2034632827 hasConcept C2781161787 @default.
• W2034632827 hasConcept C502032728 @default.
• W2034632827 hasConcept C55493867 @default.
• W2034632827 hasConcept C71924100 @default.
• W2034632827 hasConcept C80631254 @default.
• W2034632827 hasConcept C86803240 @default.
• W2034632827 hasConceptScore W2034632827C118716 @default.
• W2034632827 hasConceptScore W2034632827C126322002 @default.
• W2034632827 hasConceptScore W2034632827C134018914 @default.
• W2034632827 hasConceptScore W2034632827C170493617 @default.
• W2034632827 hasConceptScore W2034632827C181199279 @default.
• W2034632827 hasConceptScore W2034632827C185592680 @default.
• W2034632827 hasConceptScore W2034632827C24998067 @default.
• W2034632827 hasConceptScore W2034632827C2777995097 @default.
• W2034632827 hasConceptScore W2034632827C2779134260 @default.
• W2034632827 hasConceptScore W2034632827C2779178603 @default.
• W2034632827 hasConceptScore W2034632827C2779276759 @default.
• W2034632827 hasConceptScore W2034632827C2779652256 @default.
• W2034632827 hasConceptScore W2034632827C2781161787 @default.
• W2034632827 hasConceptScore W2034632827C502032728 @default.
• W2034632827 hasConceptScore W2034632827C55493867 @default.
• W2034632827 hasConceptScore W2034632827C71924100 @default.
• W2034632827 hasConceptScore W2034632827C80631254 @default.
• W2034632827 hasConceptScore W2034632827C86803240 @default.
• W2034632827 hasIssue "2" @default.
• W2034632827 hasLocation W20346328271 @default.
• W2034632827 hasLocation W20346328272 @default.
• W2034632827 hasOpenAccess W2034632827 @default.
• W2034632827 hasPrimaryLocation W20346328271 @default.
• W2034632827 hasRelatedWork W2017484433 @default.
• W2034632827 hasRelatedWork W2037022019 @default.
• W2034632827 hasRelatedWork W2050034731 @default.
• W2034632827 hasRelatedWork W2052655649 @default.

• next