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- W2034633030 endingPage "149" @default.
- W2034633030 startingPage "137" @default.
- W2034633030 abstract "Disease is a major cause of natural selection affecting human evolution, whether through a sudden pandemic or persistent morbidity and mortality. Recent contributions in the field of ancient pathogen genomics have advanced our understanding of the antiquity and nature of human-pathogen interactions through time. Technical advancements have facilitated the recovery, enrichment, and high-throughput sequencing of pathogen and parasite DNA from archived and archaeological remains. These time-stamped genomes are crucial for calibrating molecular clocks to infer the timing of evolutionary events, while providing finer-grain resolution to phylogenetic reconstructions and complex biogeographical patterns. Additionally, genome scale data allow better identification of substitutions linked to adaptations of the pathogen to their human hosts. As methodology continues to improve, ancient genomes of humans and their diverse microbiomes from a range of eras and archaeological contexts will enable population-level ancient analyses in the near future and a better understanding of their co-evolutionary history." @default.
- W2034633030 created "2016-06-24" @default.
- W2034633030 creator A5034957153 @default.
- W2034633030 creator A5083403386 @default.
- W2034633030 date "2015-02-01" @default.
- W2034633030 modified "2023-10-17" @default.
- W2034633030 title "Ancient pathogen genomics: insights into timing and adaptation" @default.
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