FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034634528> ?p ?o ?g. }

• W2034634528 endingPage "34" @default.
• W2034634528 startingPage "28" @default.
• W2034634528 abstract "The effect of isoflurane on postsynaptic neurons was studied by intracellular recordings from rat hippocampus and human neocortex in vitro. Isoflurane caused a hyperpolarization of the cell membrane. The hyperpolarization was reversed (although incompletely in some neurons) by increasing the membrane potential. The reversal potential was -80 +/- 12 mV (mean +/- S.D.) or 12 +/- 6 mV negative to the resting membrane potential. Potassium channel blockers reduced the isoflurane-induced hyperpolarization, while chloride loading was without effect. The transient depolarization preceding the hyperpolarization in some of the neurons was not reversed by hyperpolarization. The action potential was prolonged by 19 +/- 3% due to a slower rate of rise. The rise time was almost doubled. Firing threshold was increased by 4 +/- 3 mV (relative to the reference electrode). Subthreshold inward rectification was reduced or abolished. Some cells showed subthreshold outward rectification during isoflurane administration. These results suggest that isoflurane depressed neuronal excitability by (1) hyperpolarizing the cell membrane, at least partly by an increase in potassium conductance, (2) slowing the rate of rise of the action potential, presumably due to interference with the fast sodium channel, (3) decreasing subthreshold inward rectification and (4) increasing firing threshold." @default.
• W2034634528 created "2016-06-24" @default.
• W2034634528 creator A5001400020 @default.
• W2034634528 creator A5006360278 @default.
• W2034634528 date "1990-01-01" @default.
• W2034634528 modified "2023-10-15" @default.
• W2034634528 title "Mechanisms concerned in the direct effect of isoflurane on rat hippocampal and human neocortical neurons" @default.
• W2034634528 cites W1253581711 @default.
• W2034634528 cites W1953088445 @default.
• W2034634528 cites W1968860350 @default.
• W2034634528 cites W1971173188 @default.
• W2034634528 cites W1985940938 @default.
• W2034634528 cites W1988221676 @default.
• W2034634528 cites W1990326404 @default.
• W2034634528 cites W1990957805 @default.
• W2034634528 cites W1995420280 @default.
• W2034634528 cites W2001509445 @default.
• W2034634528 cites W2001539070 @default.
• W2034634528 cites W2002422188 @default.
• W2034634528 cites W2005291443 @default.
• W2034634528 cites W2039546798 @default.
• W2034634528 cites W2046920078 @default.
• W2034634528 cites W2066722424 @default.
• W2034634528 cites W2066728379 @default.
• W2034634528 cites W2068170628 @default.
• W2034634528 cites W2073445363 @default.
• W2034634528 cites W2077573641 @default.
• W2034634528 cites W2078265223 @default.
• W2034634528 cites W2084647496 @default.
• W2034634528 cites W2085741321 @default.
• W2034634528 cites W2086062850 @default.
• W2034634528 cites W2093173175 @default.
• W2034634528 cites W2093963631 @default.
• W2034634528 cites W2095354414 @default.
• W2034634528 cites W2102414318 @default.
• W2034634528 cites W2112775014 @default.
• W2034634528 cites W2119397841 @default.
• W2034634528 cites W2141282766 @default.
• W2034634528 cites W2244951642 @default.
• W2034634528 cites W2288331821 @default.
• W2034634528 cites W2399114637 @default.
• W2034634528 cites W2401059362 @default.
• W2034634528 cites W2412113717 @default.
• W2034634528 doi "https://doi.org/10.1016/0006-8993(90)90517-f" @default.
• W2034634528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2302577" @default.
• W2034634528 hasPublicationYear "1990" @default.
• W2034634528 type Work @default.
• W2034634528 sameAs 2034634528 @default.
• W2034634528 citedByCount "59" @default.
• W2034634528 countsByYear W20346345282012 @default.
• W2034634528 countsByYear W20346345282015 @default.
• W2034634528 countsByYear W20346345282016 @default.
• W2034634528 countsByYear W20346345282017 @default.
• W2034634528 countsByYear W20346345282019 @default.
• W2034634528 countsByYear W20346345282020 @default.
• W2034634528 countsByYear W20346345282021 @default.
• W2034634528 countsByYear W20346345282022 @default.
• W2034634528 crossrefType "journal-article" @default.
• W2034634528 hasAuthorship W2034634528A5001400020 @default.
• W2034634528 hasAuthorship W2034634528A5006360278 @default.
• W2034634528 hasConcept C12554922 @default.
• W2034634528 hasConcept C131453863 @default.
• W2034634528 hasConcept C148762608 @default.
• W2034634528 hasConcept C158494493 @default.
• W2034634528 hasConcept C169760540 @default.
• W2034634528 hasConcept C178790620 @default.
• W2034634528 hasConcept C181911157 @default.
• W2034634528 hasConcept C185592680 @default.
• W2034634528 hasConcept C2776359302 @default.
• W2034634528 hasConcept C2777222312 @default.
• W2034634528 hasConcept C4141045 @default.
• W2034634528 hasConcept C55493867 @default.
• W2034634528 hasConcept C66974803 @default.
• W2034634528 hasConcept C83743174 @default.
• W2034634528 hasConcept C86803240 @default.
• W2034634528 hasConcept C93872552 @default.
• W2034634528 hasConceptScore W2034634528C12554922 @default.
• W2034634528 hasConceptScore W2034634528C131453863 @default.
• W2034634528 hasConceptScore W2034634528C148762608 @default.
• W2034634528 hasConceptScore W2034634528C158494493 @default.
• W2034634528 hasConceptScore W2034634528C169760540 @default.
• W2034634528 hasConceptScore W2034634528C178790620 @default.
• W2034634528 hasConceptScore W2034634528C181911157 @default.
• W2034634528 hasConceptScore W2034634528C185592680 @default.
• W2034634528 hasConceptScore W2034634528C2776359302 @default.
• W2034634528 hasConceptScore W2034634528C2777222312 @default.
• W2034634528 hasConceptScore W2034634528C4141045 @default.
• W2034634528 hasConceptScore W2034634528C55493867 @default.
• W2034634528 hasConceptScore W2034634528C66974803 @default.
• W2034634528 hasConceptScore W2034634528C83743174 @default.
• W2034634528 hasConceptScore W2034634528C86803240 @default.
• W2034634528 hasConceptScore W2034634528C93872552 @default.
• W2034634528 hasIssue "1" @default.
• W2034634528 hasLocation W20346345281 @default.
• W2034634528 hasLocation W20346345282 @default.
• W2034634528 hasOpenAccess W2034634528 @default.
• W2034634528 hasPrimaryLocation W20346345281 @default.
• W2034634528 hasRelatedWork W1973357121 @default.

• next