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• W2034636421 abstract "Besides their well-described use as delivery systems for water-soluble drugs, liposomes have the ability to act as a solubilizing agent for drugs with low aqueous solubility. However, a key limitation in exploiting liposome technology is the availability of scalable, low-cost production methods for the preparation of liposomes. Here we describe a new method, using microfluidics, to prepare liposomal solubilising systems which can incorporate low solubility drugs (in this case propofol). The setup, based on a chaotic advection micromixer, showed high drug loading (41 mol%) of propofol as well as the ability to manufacture vesicles with at prescribed sizes (between 50 and 450 nm) in a high-throughput setting. Our results demonstrate the ability of merging liposome manufacturing and drug encapsulation in a single process step, leading to an overall reduced process time. These studies emphasise the flexibility and ease of applying lab-on-a-chip microfluidics for the solubilisation of poorly water-soluble drugs." @default.
• W2034636421 created "2016-06-24" @default.
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• W2034636421 date "2015-05-01" @default.
• W2034636421 modified "2023-09-29" @default.
• W2034636421 title "Microfluidic-controlled manufacture of liposomes for the solubilisation of a poorly water soluble drug" @default.
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• W2034636421 doi "https://doi.org/10.1016/j.ijpharm.2015.02.063" @default.
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