Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034636421> ?p ?o ?g. }
- W2034636421 endingPage "130" @default.
- W2034636421 startingPage "122" @default.
- W2034636421 abstract "Besides their well-described use as delivery systems for water-soluble drugs, liposomes have the ability to act as a solubilizing agent for drugs with low aqueous solubility. However, a key limitation in exploiting liposome technology is the availability of scalable, low-cost production methods for the preparation of liposomes. Here we describe a new method, using microfluidics, to prepare liposomal solubilising systems which can incorporate low solubility drugs (in this case propofol). The setup, based on a chaotic advection micromixer, showed high drug loading (41 mol%) of propofol as well as the ability to manufacture vesicles with at prescribed sizes (between 50 and 450 nm) in a high-throughput setting. Our results demonstrate the ability of merging liposome manufacturing and drug encapsulation in a single process step, leading to an overall reduced process time. These studies emphasise the flexibility and ease of applying lab-on-a-chip microfluidics for the solubilisation of poorly water-soluble drugs." @default.
- W2034636421 created "2016-06-24" @default.
- W2034636421 creator A5011580238 @default.
- W2034636421 creator A5030975247 @default.
- W2034636421 creator A5032456308 @default.
- W2034636421 creator A5068311279 @default.
- W2034636421 date "2015-05-01" @default.
- W2034636421 modified "2023-09-29" @default.
- W2034636421 title "Microfluidic-controlled manufacture of liposomes for the solubilisation of a poorly water soluble drug" @default.
- W2034636421 cites W1557750548 @default.
- W2034636421 cites W1776109014 @default.
- W2034636421 cites W1988572643 @default.
- W2034636421 cites W2001721477 @default.
- W2034636421 cites W2003325085 @default.
- W2034636421 cites W2009858479 @default.
- W2034636421 cites W2011784577 @default.
- W2034636421 cites W2013141559 @default.
- W2034636421 cites W2018595897 @default.
- W2034636421 cites W2023976671 @default.
- W2034636421 cites W2024707548 @default.
- W2034636421 cites W2045564776 @default.
- W2034636421 cites W2048197073 @default.
- W2034636421 cites W2064966167 @default.
- W2034636421 cites W2070336138 @default.
- W2034636421 cites W2070808114 @default.
- W2034636421 cites W2078426823 @default.
- W2034636421 cites W2079812848 @default.
- W2034636421 cites W2080383723 @default.
- W2034636421 cites W2086187432 @default.
- W2034636421 cites W2094310647 @default.
- W2034636421 cites W2120764900 @default.
- W2034636421 cites W2125470506 @default.
- W2034636421 cites W2132163443 @default.
- W2034636421 cites W2166458266 @default.
- W2034636421 cites W4366065085 @default.
- W2034636421 doi "https://doi.org/10.1016/j.ijpharm.2015.02.063" @default.
- W2034636421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25725309" @default.
- W2034636421 hasPublicationYear "2015" @default.
- W2034636421 type Work @default.
- W2034636421 sameAs 2034636421 @default.
- W2034636421 citedByCount "110" @default.
- W2034636421 countsByYear W20346364212015 @default.
- W2034636421 countsByYear W20346364212016 @default.
- W2034636421 countsByYear W20346364212017 @default.
- W2034636421 countsByYear W20346364212018 @default.
- W2034636421 countsByYear W20346364212019 @default.
- W2034636421 countsByYear W20346364212020 @default.
- W2034636421 countsByYear W20346364212021 @default.
- W2034636421 countsByYear W20346364212022 @default.
- W2034636421 countsByYear W20346364212023 @default.
- W2034636421 crossrefType "journal-article" @default.
- W2034636421 hasAuthorship W2034636421A5011580238 @default.
- W2034636421 hasAuthorship W2034636421A5030975247 @default.
- W2034636421 hasAuthorship W2034636421A5032456308 @default.
- W2034636421 hasAuthorship W2034636421A5068311279 @default.
- W2034636421 hasBestOaLocation W20346364212 @default.
- W2034636421 hasConcept C150903083 @default.
- W2034636421 hasConcept C155574463 @default.
- W2034636421 hasConcept C171250308 @default.
- W2034636421 hasConcept C178790620 @default.
- W2034636421 hasConcept C185154212 @default.
- W2034636421 hasConcept C185592680 @default.
- W2034636421 hasConcept C192562407 @default.
- W2034636421 hasConcept C2779820397 @default.
- W2034636421 hasConcept C2780035454 @default.
- W2034636421 hasConcept C2780982322 @default.
- W2034636421 hasConcept C2781047461 @default.
- W2034636421 hasConcept C71924100 @default.
- W2034636421 hasConcept C8673954 @default.
- W2034636421 hasConcept C86803240 @default.
- W2034636421 hasConcept C98274493 @default.
- W2034636421 hasConceptScore W2034636421C150903083 @default.
- W2034636421 hasConceptScore W2034636421C155574463 @default.
- W2034636421 hasConceptScore W2034636421C171250308 @default.
- W2034636421 hasConceptScore W2034636421C178790620 @default.
- W2034636421 hasConceptScore W2034636421C185154212 @default.
- W2034636421 hasConceptScore W2034636421C185592680 @default.
- W2034636421 hasConceptScore W2034636421C192562407 @default.
- W2034636421 hasConceptScore W2034636421C2779820397 @default.
- W2034636421 hasConceptScore W2034636421C2780035454 @default.
- W2034636421 hasConceptScore W2034636421C2780982322 @default.
- W2034636421 hasConceptScore W2034636421C2781047461 @default.
- W2034636421 hasConceptScore W2034636421C71924100 @default.
- W2034636421 hasConceptScore W2034636421C8673954 @default.
- W2034636421 hasConceptScore W2034636421C86803240 @default.
- W2034636421 hasConceptScore W2034636421C98274493 @default.
- W2034636421 hasFunder F4320323026 @default.
- W2034636421 hasIssue "1-2" @default.
- W2034636421 hasLocation W20346364211 @default.
- W2034636421 hasLocation W20346364212 @default.
- W2034636421 hasLocation W20346364213 @default.
- W2034636421 hasLocation W20346364214 @default.
- W2034636421 hasOpenAccess W2034636421 @default.
- W2034636421 hasPrimaryLocation W20346364211 @default.
- W2034636421 hasRelatedWork W2034636421 @default.
- W2034636421 hasRelatedWork W2181379298 @default.
- W2034636421 hasRelatedWork W2795989070 @default.
- W2034636421 hasRelatedWork W2912545573 @default.