Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034639968> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2034639968 endingPage "103" @default.
- W2034639968 startingPage "95" @default.
- W2034639968 abstract "Central neurons undergo cell death after axotomy. One of the signaling pathways for this process is oxidative modification of one or more critical sulfhydryls in association with superoxide generation within mitochondria. Agents that reduce oxidized sulfhydryls are neuroprotective of axotomized retinal ganglion cells, and we hypothesized that this occurs via reversal of the effects of mitochondrial-produced superoxide. To study this, we measured the ability of the novel borane−phosphine complex drugs bis(3-propionic acid methyl ester)phenylphosphine borane complex (PB1) and (3-propionic acid methyl ester)diphenylphosphine borane complex (PB2) to inhibit the death of neuron-like RGC-5 cells induced by perturbation of the mitochondrial electron transport chain. We found that borane−phosphine complexes prevent neuronal cell death from superoxide produced by the redox-cycling agent menadione and the complex III inhibitor antimycin A, which produce superoxide toward the cytoplasm and matrix, but not the complex I inhibitor rotenone, which produces superoxide in the matrix alone. The ability of these disulfide reductants to prevent cell death may be predicted by the topology of superoxide production with respect to the mitochondrial matrix and extramitochondrial space." @default.
- W2034639968 created "2016-06-24" @default.
- W2034639968 creator A5023191603 @default.
- W2034639968 creator A5028788332 @default.
- W2034639968 creator A5064774144 @default.
- W2034639968 creator A5091270306 @default.
- W2034639968 date "2009-11-17" @default.
- W2034639968 modified "2023-10-16" @default.
- W2034639968 title "Effectiveness of Novel Borane−Phosphine Complexes in Inhibiting Cell Death Depends on the Source of Superoxide Production Induced by Blockade of Mitochondrial Electron Transport" @default.
- W2034639968 cites W1906407967 @default.
- W2034639968 cites W1911339081 @default.
- W2034639968 cites W1975668301 @default.
- W2034639968 cites W1978631786 @default.
- W2034639968 cites W1983078193 @default.
- W2034639968 cites W1984156802 @default.
- W2034639968 cites W1988736257 @default.
- W2034639968 cites W2025152430 @default.
- W2034639968 cites W2039339564 @default.
- W2034639968 cites W2042769356 @default.
- W2034639968 cites W2047029471 @default.
- W2034639968 cites W2058203018 @default.
- W2034639968 cites W2071391964 @default.
- W2034639968 cites W2079520663 @default.
- W2034639968 cites W2080854912 @default.
- W2034639968 cites W2087561593 @default.
- W2034639968 cites W2135406143 @default.
- W2034639968 doi "https://doi.org/10.1021/cn900024r" @default.
- W2034639968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2880810" @default.
- W2034639968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20532184" @default.
- W2034639968 hasPublicationYear "2009" @default.
- W2034639968 type Work @default.
- W2034639968 sameAs 2034639968 @default.
- W2034639968 citedByCount "7" @default.
- W2034639968 countsByYear W20346399682012 @default.
- W2034639968 countsByYear W20346399682015 @default.
- W2034639968 countsByYear W20346399682016 @default.
- W2034639968 countsByYear W20346399682017 @default.
- W2034639968 countsByYear W20346399682018 @default.
- W2034639968 crossrefType "journal-article" @default.
- W2034639968 hasAuthorship W2034639968A5023191603 @default.
- W2034639968 hasAuthorship W2034639968A5028788332 @default.
- W2034639968 hasAuthorship W2034639968A5064774144 @default.
- W2034639968 hasAuthorship W2034639968A5091270306 @default.
- W2034639968 hasBestOaLocation W20346399682 @default.
- W2034639968 hasConcept C181199279 @default.
- W2034639968 hasConcept C185592680 @default.
- W2034639968 hasConcept C190283241 @default.
- W2034639968 hasConcept C25498285 @default.
- W2034639968 hasConcept C2780795997 @default.
- W2034639968 hasConcept C28859421 @default.
- W2034639968 hasConcept C31573885 @default.
- W2034639968 hasConcept C55493867 @default.
- W2034639968 hasConcept C86803240 @default.
- W2034639968 hasConcept C95444343 @default.
- W2034639968 hasConcept C98274493 @default.
- W2034639968 hasConceptScore W2034639968C181199279 @default.
- W2034639968 hasConceptScore W2034639968C185592680 @default.
- W2034639968 hasConceptScore W2034639968C190283241 @default.
- W2034639968 hasConceptScore W2034639968C25498285 @default.
- W2034639968 hasConceptScore W2034639968C2780795997 @default.
- W2034639968 hasConceptScore W2034639968C28859421 @default.
- W2034639968 hasConceptScore W2034639968C31573885 @default.
- W2034639968 hasConceptScore W2034639968C55493867 @default.
- W2034639968 hasConceptScore W2034639968C86803240 @default.
- W2034639968 hasConceptScore W2034639968C95444343 @default.
- W2034639968 hasConceptScore W2034639968C98274493 @default.
- W2034639968 hasIssue "2" @default.
- W2034639968 hasLocation W20346399681 @default.
- W2034639968 hasLocation W20346399682 @default.
- W2034639968 hasLocation W20346399683 @default.
- W2034639968 hasLocation W20346399684 @default.
- W2034639968 hasOpenAccess W2034639968 @default.
- W2034639968 hasPrimaryLocation W20346399681 @default.
- W2034639968 hasRelatedWork W1988725105 @default.
- W2034639968 hasRelatedWork W2034773528 @default.
- W2034639968 hasRelatedWork W2037157726 @default.
- W2034639968 hasRelatedWork W2051208451 @default.
- W2034639968 hasRelatedWork W2077655479 @default.
- W2034639968 hasRelatedWork W2095198015 @default.
- W2034639968 hasRelatedWork W2147934559 @default.
- W2034639968 hasRelatedWork W2995727304 @default.
- W2034639968 hasRelatedWork W1517805603 @default.
- W2034639968 hasRelatedWork W1593223226 @default.
- W2034639968 hasVolume "1" @default.
- W2034639968 isParatext "false" @default.
- W2034639968 isRetracted "false" @default.
- W2034639968 magId "2034639968" @default.
- W2034639968 workType "article" @default.