Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034641720> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2034641720 endingPage "31" @default.
- W2034641720 startingPage "29" @default.
- W2034641720 abstract "<h3>Abstract</h3> Age-related macular degeneration (AMD) is a common sight-threatening disease of older adults and treatment options are needed. Abnormalities of retinal pigment epithelium (RPE), supporting cells to photoreceptors and capillaries, are a hallmark. Clinical optical coherence tomography (OCT) imaging reveals hyperreflective foci (HRF) that confer risk for end-stage disease and are attributed to ectopic out-of-layer RPE. Using longitudinal OCT imaging of AMD patients, we demonstrate that the trajectory of one HRF form, RPE plume, parallels the retinal Henle fiber layer. Histology shows fully pigmented cells approaching and contacting retinal capillaries with RPE organelles dispersing along Müller glia columns. We used immunohistochemistry and a system of morphologic phenotypes to assess RPE functional repertoire in AMD. RPE corresponding to HRF loses immunoreactivity for retinoid processing proteins RPE65 and CRALBP, and gains immunoreactivity for immune cell markers CD68 and CD163. Müller glia retain CRALBP immunoreactivity. Gain- and loss-of-function for RPE starts with individual in-layer cells and extends to all abnormal phenotypes. Down-regulated RPE retinoid handling may contribute to slowed rod vision while Müller glia sustain cone vision. Ectopic RPE corresponding to HRF are emblematic of widespread transdifferentiation, motivating treatments targeting AMD pathology earlier than the initiation of atrophy. Data can propel new biomarkers and therapeutic strategies for AMD. <h3>One Sentence Summary</h3> In age-related macular degeneration retinal pigment epithelial cells transdifferentiate and migrate into the retina where they are clinically visible progression risk indicators." @default.
- W2034641720 created "2016-06-24" @default.
- W2034641720 creator A5006953213 @default.
- W2034641720 creator A5021200285 @default.
- W2034641720 creator A5070713721 @default.
- W2034641720 date "1990-07-07" @default.
- W2034641720 modified "2023-09-26" @default.
- W2034641720 title "Care of the suddenly bereaved." @default.
- W2034641720 cites W1974144383 @default.
- W2034641720 cites W1974210802 @default.
- W2034641720 cites W2064984225 @default.
- W2034641720 cites W2135529549 @default.
- W2034641720 doi "https://doi.org/10.1136/bmj.301.6742.29" @default.
- W2034641720 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1663383" @default.
- W2034641720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2383706" @default.
- W2034641720 hasPublicationYear "1990" @default.
- W2034641720 type Work @default.
- W2034641720 sameAs 2034641720 @default.
- W2034641720 citedByCount "39" @default.
- W2034641720 countsByYear W20346417202014 @default.
- W2034641720 countsByYear W20346417202017 @default.
- W2034641720 countsByYear W20346417202022 @default.
- W2034641720 crossrefType "journal-article" @default.
- W2034641720 hasAuthorship W2034641720A5006953213 @default.
- W2034641720 hasAuthorship W2034641720A5021200285 @default.
- W2034641720 hasAuthorship W2034641720A5070713721 @default.
- W2034641720 hasBestOaLocation W20346417201 @default.
- W2034641720 hasConcept C118487528 @default.
- W2034641720 hasConcept C142724271 @default.
- W2034641720 hasConcept C169760540 @default.
- W2034641720 hasConcept C186198217 @default.
- W2034641720 hasConcept C201750760 @default.
- W2034641720 hasConcept C2776403814 @default.
- W2034641720 hasConcept C2777093970 @default.
- W2034641720 hasConcept C2777102633 @default.
- W2034641720 hasConcept C2777585161 @default.
- W2034641720 hasConcept C2778024200 @default.
- W2034641720 hasConcept C2780724529 @default.
- W2034641720 hasConcept C2780827179 @default.
- W2034641720 hasConcept C28328180 @default.
- W2034641720 hasConcept C71924100 @default.
- W2034641720 hasConcept C86803240 @default.
- W2034641720 hasConcept C95444343 @default.
- W2034641720 hasConceptScore W2034641720C118487528 @default.
- W2034641720 hasConceptScore W2034641720C142724271 @default.
- W2034641720 hasConceptScore W2034641720C169760540 @default.
- W2034641720 hasConceptScore W2034641720C186198217 @default.
- W2034641720 hasConceptScore W2034641720C201750760 @default.
- W2034641720 hasConceptScore W2034641720C2776403814 @default.
- W2034641720 hasConceptScore W2034641720C2777093970 @default.
- W2034641720 hasConceptScore W2034641720C2777102633 @default.
- W2034641720 hasConceptScore W2034641720C2777585161 @default.
- W2034641720 hasConceptScore W2034641720C2778024200 @default.
- W2034641720 hasConceptScore W2034641720C2780724529 @default.
- W2034641720 hasConceptScore W2034641720C2780827179 @default.
- W2034641720 hasConceptScore W2034641720C28328180 @default.
- W2034641720 hasConceptScore W2034641720C71924100 @default.
- W2034641720 hasConceptScore W2034641720C86803240 @default.
- W2034641720 hasConceptScore W2034641720C95444343 @default.
- W2034641720 hasIssue "6742" @default.
- W2034641720 hasLocation W20346417201 @default.
- W2034641720 hasLocation W20346417202 @default.
- W2034641720 hasLocation W20346417203 @default.
- W2034641720 hasLocation W20346417204 @default.
- W2034641720 hasOpenAccess W2034641720 @default.
- W2034641720 hasPrimaryLocation W20346417201 @default.
- W2034641720 hasRelatedWork W1825190414 @default.
- W2034641720 hasRelatedWork W2009115348 @default.
- W2034641720 hasRelatedWork W2029580475 @default.
- W2034641720 hasRelatedWork W2412978246 @default.
- W2034641720 hasRelatedWork W2770908101 @default.
- W2034641720 hasRelatedWork W2790585032 @default.
- W2034641720 hasRelatedWork W3025363008 @default.
- W2034641720 hasRelatedWork W4214587971 @default.
- W2034641720 hasRelatedWork W4312474186 @default.
- W2034641720 hasRelatedWork W2470598750 @default.
- W2034641720 hasVolume "301" @default.
- W2034641720 isParatext "false" @default.
- W2034641720 isRetracted "false" @default.
- W2034641720 magId "2034641720" @default.
- W2034641720 workType "article" @default.