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• W2034642967 abstract "In this review, the authors outline a clinical approach to frontotemporal lobar degeneration (FTLD), a term coined to describe a pathology associated with atrophy of the frontal and temporal lobes commonly seen with abnormal protein aggregates. It accounts for ∼10% of pathologically confirmed dementias. The three clinical syndromes associated with FTLD are jointly classified as frontotemporal dementia (FTD) and include behavioral variant frontotemporal dementia (bvFTD), nonfluent-agrammatic primary progressive aphasia (nfvPPA), and semantic variant PPA (svPPA; left: l-svPPA and right: r-svPPA). All syndromes have differential impairment in behavioral (bvFTD; r-svPPA), executive (bvFTD; nfvPPA), and language (nfvPPA; svPPA) functions early in the disease course. With all three there is relative sparing of short-term memory and visuospatial abilities early on, and with the two language syndromes, nfvPPA and svPPA, behavior is also intact. Symptoms are associated with specific atrophy patterns, lending unique imaging signatures to each syndrome (frontal: bvFTD and nfvPPA; temporal: svPPA). Common proteinopathies involve accumulation of tau, transactive response DNA binding protein 43, and fusion in sarcoma protein. Parkinsonism presents in all syndromes, especially cases with tau pathology and <i>MAPT</i> or <i>GRN</i> mutations. nfvPPA often has corticobasal degeneration or progressive supranuclear palsy as the underlying neuropathological substrate. bvFTD co-occurs with motor neuron disease in ∼15% of cases, and many such cases are due to <i>C9Orf72</i> mutations. Other common genetic mutations in FTLD involve <i>GRN</i> and <i>MAPT</i>. Behavioral symptoms are best managed by selective serotonin reuptake inhibitors, while atypical antipsychotics should be used with caution given side effects. Promising etiologic treatments include anti-tau antibodies, antisense oligonucleotides, and progranulin enhancers." @default.
• W2034642967 created "2016-06-24" @default.
• W2034642967 creator A5046120768 @default.
• W2034642967 creator A5079035130 @default.
• W2034642967 date "2014-06-25" @default.
• W2034642967 modified "2023-10-10" @default.
• W2034642967 title "Frontotemporal Lobar Degeneration: A Clinical Approach" @default.
• W2034642967 cites W1511517753 @default.
• W2034642967 cites W1684131967 @default.
• W2034642967 cites W1968385408 @default.
• W2034642967 cites W1971073983 @default.
• W2034642967 cites W1974504862 @default.
• W2034642967 cites W1974700143 @default.
• W2034642967 cites W1974760231 @default.
• W2034642967 cites W1977257077 @default.
• W2034642967 cites W1985305469 @default.
• W2034642967 cites W1987310343 @default.
• W2034642967 cites W1995679565 @default.
• W2034642967 cites W1996314668 @default.
• W2034642967 cites W1998752629 @default.
• W2034642967 cites W2001683831 @default.
• W2034642967 cites W2003618511 @default.
• W2034642967 cites W2004375746 @default.
• W2034642967 cites W2005731595 @default.
• W2034642967 cites W2009046537 @default.
• W2034642967 cites W2009870816 @default.
• W2034642967 cites W2015683060 @default.
• W2034642967 cites W2022641202 @default.
• W2034642967 cites W2024034758 @default.
• W2034642967 cites W2026252450 @default.
• W2034642967 cites W2026273357 @default.
• W2034642967 cites W2027460468 @default.
• W2034642967 cites W2028943878 @default.
• W2034642967 cites W2031964319 @default.
• W2034642967 cites W2032355167 @default.
• W2034642967 cites W2034469326 @default.
• W2034642967 cites W2037132804 @default.
• W2034642967 cites W2037166708 @default.
• W2034642967 cites W2040639372 @default.
• W2034642967 cites W2041964860 @default.
• W2034642967 cites W2045671840 @default.
• W2034642967 cites W2050609730 @default.
• W2034642967 cites W2058247742 @default.
• W2034642967 cites W2059809766 @default.
• W2034642967 cites W2062024523 @default.
• W2034642967 cites W2069451534 @default.
• W2034642967 cites W2074209215 @default.
• W2034642967 cites W2074608237 @default.
• W2034642967 cites W2074742396 @default.
• W2034642967 cites W2077311804 @default.
• W2034642967 cites W2081838509 @default.
• W2034642967 cites W2085027326 @default.
• W2034642967 cites W2086398877 @default.
• W2034642967 cites W2090318965 @default.
• W2034642967 cites W2094206043 @default.
• W2034642967 cites W2094973575 @default.
• W2034642967 cites W2098219309 @default.
• W2034642967 cites W2099880194 @default.
• W2034642967 cites W2100387103 @default.
• W2034642967 cites W2102613865 @default.
• W2034642967 cites W2103390384 @default.
• W2034642967 cites W2105846299 @default.
• W2034642967 cites W2106046611 @default.
• W2034642967 cites W2114133705 @default.
• W2034642967 cites W2114452946 @default.
• W2034642967 cites W2120361659 @default.
• W2034642967 cites W2121101368 @default.
• W2034642967 cites W2123985800 @default.
• W2034642967 cites W2128030851 @default.
• W2034642967 cites W2128739333 @default.
• W2034642967 cites W2130213426 @default.
• W2034642967 cites W2135597459 @default.
• W2034642967 cites W2136557657 @default.
• W2034642967 cites W2138190873 @default.
• W2034642967 cites W2138875605 @default.
• W2034642967 cites W2144707045 @default.
• W2034642967 cites W2154633730 @default.
• W2034642967 cites W2154945114 @default.
• W2034642967 cites W2155857429 @default.
• W2034642967 cites W2159716692 @default.
• W2034642967 cites W2162597247 @default.
• W2034642967 cites W2171005679 @default.
• W2034642967 cites W2990111830 @default.
• W2034642967 doi "https://doi.org/10.1055/s-0034-1381735" @default.
• W2034642967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24963678" @default.
• W2034642967 hasPublicationYear "2014" @default.
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