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• W2034643906 abstract "The synapses formed by the mossy fiber (MF) axons of hippocampal dentate gyrus granule neurons onto CA3 pyramidal neurons exhibit an intriguing form of experience-dependent synaptic plasticity that is induced and expressed presynaptically. In contrast to most other CNS synapses, long-term potentiation (LTP) at the MF–CA3 synapse is readily induced even during blockade of postsynaptic glutamate receptors. Furthermore, blocking voltage-gated Ca 2+ channels prevents MF-LTP, supporting an involvement of presynaptic Ca 2+ signaling via voltage-gated Ca 2+ channels in MF-LTP induction. We examined the contribution of activity in both dentate granule cell somata and MF terminals to MF-LTP. We found that the induction of stable MF-LTP requires tetanization-induced action potentials not only at MF boutons, but also at dentate granule cell somata. Similarly, blocking Ca 2+ influx via voltage-gated Ca 2+ channels only at the granule cell soma was sufficient to disrupt MF-LTP. Finally, blocking protein synthesis or blocking fast axonal transport mechanisms via disruption of axonal tubulin filaments resulted in decremental MF-LTP. Collectively, these data suggest that—in addition to Ca 2+ influx at the MF terminals—induction of MF synaptic plasticity requires action potential-dependent Ca 2+ signaling at granule cell somata, protein synthesis, and fast axonal transport along MFs. A parsimonious interpretation of these results is that somatic activity triggers protein synthesis at the soma; newly synthesized proteins are then transported to MF terminals, where they contribute to the stabilization of MF-LTP. Finally, the present data imply that synaptic plasticity at the MF–CA3 synapse can be affected by local modulation of somatic and presynaptic Ca 2+ channel activity." @default.
• W2034643906 created "2016-06-24" @default.
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• W2034643906 date "2010-09-29" @default.
• W2034643906 modified "2023-09-26" @default.
• W2034643906 title "Stable Mossy Fiber Long-Term Potentiation Requires Calcium Influx at the Granule Cell Soma, Protein Synthesis, and Microtubule-Dependent Axonal Transport" @default.
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• W2034643906 doi "https://doi.org/10.1523/jneurosci.1847-10.2010" @default.
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