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• W2034643995 endingPage "S124" @default.
• W2034643995 startingPage "S119" @default.
• W2034643995 abstract "The seven botulinum neurotoxin serotypes share less than 50% sequence homology and are immunologically distinct. The neurotoxins inhibit release of the neurotransmitter acetylcholine from the axon terminals of motor neurons, preganglionic sympathetic and parasympathetic neurons, and postganglionic parasympathetic nerves by a multi-step mechanism that differs slightly, but significantly, for each serotype. The inhibition is long lasting but temporary. The resulting muscle paralysis has provided the basis for therapeutic use of botulinum toxin types A and B in a variety of focal dystonias. The safety of the botulinum toxins, when administered focally, has permitted their widespread use in a number of other painful conditions." @default.
• W2034643995 created "2016-06-24" @default.
• W2034643995 creator A5003185733 @default.
• W2034643995 date "2002-11-01" @default.
• W2034643995 modified "2023-09-30" @default.
• W2034643995 title "Therapeutic Use of Botulinum Toxins: Background and History" @default.
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• W2034643995 doi "https://doi.org/10.1097/00002508-200211001-00002" @default.
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