FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034644920> ?p ?o ?g. }

• W2034644920 endingPage "1051" @default.
• W2034644920 startingPage "1044" @default.
• W2034644920 abstract "Non—insulin-dependent diabetes mellitus (NIDDM) is associated histopathologically with islet amyloid deposits of which a major component is islet amyloid polypeptide (IAPP)/amylin. We examined whether endogenous IAPP controls insulin secretion via a local effect within pancreatic islets and whether overexpression of this peptide contributes to pancreatic β-cell dysfunction in this disease. Transgenic mice expressing human IAPP in pancreatic β cells were used in this study. Human IAPP expression did not influence the mouse proinsulin mRNA level and insulin content. Glucose-induced insulin secretion was decreased in the isolated pancreatic islets of transgenic mice. MIN6, a glucose-responsive pancreatic β-cell line, was transfected with human IAPP cDNA by a lipofectin method. Human IAPP expression was confirmed by RNA blot and immunohistochemical analysis. In two transfectants expressing the largest amount of human IAPP, insulin secretion was increased in response to glucose stimulation; however, the magnitude of the insulin response in cells transfected with human IAPP was smaller than in control clones. Insulin content was not influenced by the expression. We conclude that endogenous IAPP inhibits insulin secretion via an autocrine effect within pancreatic islets, and that the impaired insulin secretion in this disease may be partly caused by overexpression of IAPP." @default.
• W2034644920 created "2016-06-24" @default.
• W2034644920 creator A5003742850 @default.
• W2034644920 creator A5004103620 @default.
• W2034644920 creator A5008639301 @default.
• W2034644920 creator A5008960691 @default.
• W2034644920 creator A5014959654 @default.
• W2034644920 creator A5015186364 @default.
• W2034644920 creator A5037698763 @default.
• W2034644920 creator A5044592843 @default.
• W2034644920 creator A5054136651 @default.
• W2034644920 creator A5055276608 @default.
• W2034644920 creator A5084052847 @default.
• W2034644920 date "1997-09-01" @default.
• W2034644920 modified "2023-10-17" @default.
• W2034644920 title "Expression of human islet amyloid polypeptide/amylin impairs insulin secretion in mouse pancreatic β cells" @default.
• W2034644920 cites W1557198624 @default.
• W2034644920 cites W1964172387 @default.
• W2034644920 cites W1967006902 @default.
• W2034644920 cites W1967330275 @default.
• W2034644920 cites W1974902976 @default.
• W2034644920 cites W1976148109 @default.
• W2034644920 cites W1978886782 @default.
• W2034644920 cites W1987133531 @default.
• W2034644920 cites W1991182327 @default.
• W2034644920 cites W1997522955 @default.
• W2034644920 cites W2004210837 @default.
• W2034644920 cites W2012155412 @default.
• W2034644920 cites W2029647964 @default.
• W2034644920 cites W2034109892 @default.
• W2034644920 cites W2034637066 @default.
• W2034644920 cites W2040205230 @default.
• W2034644920 cites W2048162805 @default.
• W2034644920 cites W2056007483 @default.
• W2034644920 cites W2068477603 @default.
• W2034644920 cites W2069723292 @default.
• W2034644920 cites W2077402733 @default.
• W2034644920 cites W2089827248 @default.
• W2034644920 cites W2096691913 @default.
• W2034644920 cites W2097975060 @default.
• W2034644920 cites W2141063928 @default.
• W2034644920 cites W2155926956 @default.
• W2034644920 cites W2160949543 @default.
• W2034644920 doi "https://doi.org/10.1016/s0026-0495(97)90276-6" @default.
• W2034644920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9284894" @default.
• W2034644920 hasPublicationYear "1997" @default.
• W2034644920 type Work @default.
• W2034644920 sameAs 2034644920 @default.
• W2034644920 citedByCount "25" @default.
• W2034644920 countsByYear W20346449202012 @default.
• W2034644920 countsByYear W20346449202013 @default.
• W2034644920 countsByYear W20346449202014 @default.
• W2034644920 countsByYear W20346449202016 @default.
• W2034644920 countsByYear W20346449202018 @default.
• W2034644920 countsByYear W20346449202020 @default.
• W2034644920 countsByYear W20346449202021 @default.
• W2034644920 countsByYear W20346449202022 @default.
• W2034644920 crossrefType "journal-article" @default.
• W2034644920 hasAuthorship W2034644920A5003742850 @default.
• W2034644920 hasAuthorship W2034644920A5004103620 @default.
• W2034644920 hasAuthorship W2034644920A5008639301 @default.
• W2034644920 hasAuthorship W2034644920A5008960691 @default.
• W2034644920 hasAuthorship W2034644920A5014959654 @default.
• W2034644920 hasAuthorship W2034644920A5015186364 @default.
• W2034644920 hasAuthorship W2034644920A5037698763 @default.
• W2034644920 hasAuthorship W2034644920A5044592843 @default.
• W2034644920 hasAuthorship W2034644920A5054136651 @default.
• W2034644920 hasAuthorship W2034644920A5055276608 @default.
• W2034644920 hasAuthorship W2034644920A5084052847 @default.
• W2034644920 hasConcept C102230213 @default.
• W2034644920 hasConcept C104317684 @default.
• W2034644920 hasConcept C126322002 @default.
• W2034644920 hasConcept C134018914 @default.
• W2034644920 hasConcept C165220095 @default.
• W2034644920 hasConcept C2777633098 @default.
• W2034644920 hasConcept C2778108375 @default.
• W2034644920 hasConcept C2778563252 @default.
• W2034644920 hasConcept C2779306644 @default.
• W2034644920 hasConcept C2779855799 @default.
• W2034644920 hasConcept C2780331951 @default.
• W2034644920 hasConcept C2780705028 @default.
• W2034644920 hasConcept C49039625 @default.
• W2034644920 hasConcept C55493867 @default.
• W2034644920 hasConcept C59822182 @default.
• W2034644920 hasConcept C71924100 @default.
• W2034644920 hasConcept C86803240 @default.
• W2034644920 hasConcept C90061646 @default.
• W2034644920 hasConceptScore W2034644920C102230213 @default.
• W2034644920 hasConceptScore W2034644920C104317684 @default.
• W2034644920 hasConceptScore W2034644920C126322002 @default.
• W2034644920 hasConceptScore W2034644920C134018914 @default.
• W2034644920 hasConceptScore W2034644920C165220095 @default.
• W2034644920 hasConceptScore W2034644920C2777633098 @default.
• W2034644920 hasConceptScore W2034644920C2778108375 @default.
• W2034644920 hasConceptScore W2034644920C2778563252 @default.
• W2034644920 hasConceptScore W2034644920C2779306644 @default.
• W2034644920 hasConceptScore W2034644920C2779855799 @default.
• W2034644920 hasConceptScore W2034644920C2780331951 @default.

• next