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- W2034646004 abstract "Summary1) A remarkable decrease in the amplitude of both negative and positive slow components of direct cortical response (DCR) was found following topical application of GABOB.2) Negative slow component of the transcallosal response (TCR) was suppressed but the positive slow component was not changed. GABOB applied to a cortical region under the stimulating electrode did not show any effect on the TCR.3) A pronounced decrease in the amplitude of the negative component and a slight suppression of the positive component in the cortical somatosensory evoked potential were induced by topical application of GABOB.4) Reductions of the amplitude of the thalamic somatosensory relay muclei (VPL) and of both negative and positive components in the cortical sensory evoked potential was caused by injection of GABOB into VPL.5) The intravenously applied GABOB (5% solution, 1 ml) to the deeply anesthetized animals (with 100 mg/kg of pentobabitone) produced a decrease in the amplitude of the cortical evoked potentials. This was identical to that produced by topically applied GABOB.6) From the above results, it was elucidated that the inhibitory action of GABOB may affect the activities of the thalamus as well as the superficial cortex.7) The inhibitory action of GABOB upon the synaptic transmission of the evoked potentials was discussed." @default.
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- W2034646004 date "1963-07-01" @default.
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- W2034646004 title "THE EFFECT OF β-HYDROXY-γ-AMINOBUTYRIC ACID ON CEREBRAL ELECTRICAL ACTIVITY" @default.
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- W2034646004 doi "https://doi.org/10.1111/j.1440-1819.1963.tb00683.x" @default.
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