FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034646721> ?p ?o ?g. }

• W2034646721 endingPage "514" @default.
• W2034646721 startingPage "511" @default.
• W2034646721 abstract "The aim of this study was to test whether a recently reported polymorphism in the HERG gene coding for the rapidly activating delayed rectifier K+ channel has influence on myocardial repolarization. The length of myocardial repolarization, measured as the QT interval, has a hereditary component, but no genes that would explain the variability of repolarization have been identified in healthy subjects. QT intervals were measured from the 12-lead electrocardiogram in a random middle-aged population (226 men/187 women). The longest QT interval at any of the 12 leads (QTmax), QTV 2 , and the Tpeak-Tend interval were used as measures of repolarization. Deoxyribonucleic acid samples were genotyped for the nucleotide 2690A>C variation of the HERG gene, corresponding to the HERG K(lysine)897T(threonine) amino acid polymorphism. The allele frequencies were 0.84 (A) and 0.16 (C). Females with the genotype AC or CC had longer QTcmax (477 ± 99 ms) and Tpeak-Tend intervals (143 ± 95 ms) than females with the genotype AA (441 ± 69 ms and 116 ± 65 ms, p = 0.005 and p = 0.025, respectively). In males, the QTcmax and the Tpeak-Tend intervals did not differ between the genotypes. After adjustment for echocardiographic and various laboratory variables, the HERG K897T polymorphism remained as an independent predictor of QTcmax (p = 0.009) and the Tpeak-Tend intervals (p = 0.026) in females. The common K897T polymorphism of the HERG channel is associated with the maximal duration and transmural dispersion of ventricular repolarization in middle-aged females." @default.
• W2034646721 created "2016-06-24" @default.
• W2034646721 creator A5015136395 @default.
• W2034646721 creator A5025549582 @default.
• W2034646721 creator A5026411943 @default.
• W2034646721 creator A5031890738 @default.
• W2034646721 creator A5035866982 @default.
• W2034646721 creator A5043152183 @default.
• W2034646721 creator A5048681350 @default.
• W2034646721 creator A5049602152 @default.
• W2034646721 creator A5074393825 @default.
• W2034646721 date "2002-08-01" @default.
• W2034646721 modified "2023-09-24" @default.
• W2034646721 title "association between HERG K897T polymorphism and QT interval in middle-aged finnish women" @default.
• W2034646721 cites W1966896157 @default.
• W2034646721 cites W1968098810 @default.
• W2034646721 cites W1969839521 @default.
• W2034646721 cites W1971694756 @default.
• W2034646721 cites W1984313043 @default.
• W2034646721 cites W1985380813 @default.
• W2034646721 cites W1991515811 @default.
• W2034646721 cites W1995947202 @default.
• W2034646721 cites W1997071795 @default.
• W2034646721 cites W2002245125 @default.
• W2034646721 cites W2018414627 @default.
• W2034646721 cites W2029433670 @default.
• W2034646721 cites W2039374034 @default.
• W2034646721 cites W2046609059 @default.
• W2034646721 cites W2049210460 @default.
• W2034646721 cites W2060461813 @default.
• W2034646721 cites W2063605225 @default.
• W2034646721 cites W2067396983 @default.
• W2034646721 cites W2074705578 @default.
• W2034646721 cites W2088709361 @default.
• W2034646721 cites W2118094114 @default.
• W2034646721 cites W2119980369 @default.
• W2034646721 cites W2135884250 @default.
• W2034646721 cites W2145764563 @default.
• W2034646721 cites W2145859586 @default.
• W2034646721 cites W2331507596 @default.
• W2034646721 cites W4246000128 @default.
• W2034646721 doi "https://doi.org/10.1016/s0735-1097(02)01979-4" @default.
• W2034646721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12142119" @default.
• W2034646721 hasPublicationYear "2002" @default.
• W2034646721 type Work @default.
• W2034646721 sameAs 2034646721 @default.
• W2034646721 citedByCount "102" @default.
• W2034646721 countsByYear W20346467212012 @default.
• W2034646721 countsByYear W20346467212013 @default.
• W2034646721 countsByYear W20346467212014 @default.
• W2034646721 countsByYear W20346467212015 @default.
• W2034646721 countsByYear W20346467212016 @default.
• W2034646721 countsByYear W20346467212017 @default.
• W2034646721 countsByYear W20346467212018 @default.
• W2034646721 countsByYear W20346467212019 @default.
• W2034646721 countsByYear W20346467212021 @default.
• W2034646721 crossrefType "journal-article" @default.
• W2034646721 hasAuthorship W2034646721A5015136395 @default.
• W2034646721 hasAuthorship W2034646721A5025549582 @default.
• W2034646721 hasAuthorship W2034646721A5026411943 @default.
• W2034646721 hasAuthorship W2034646721A5031890738 @default.
• W2034646721 hasAuthorship W2034646721A5035866982 @default.
• W2034646721 hasAuthorship W2034646721A5043152183 @default.
• W2034646721 hasAuthorship W2034646721A5048681350 @default.
• W2034646721 hasAuthorship W2034646721A5049602152 @default.
• W2034646721 hasAuthorship W2034646721A5074393825 @default.
• W2034646721 hasConcept C104317684 @default.
• W2034646721 hasConcept C118441451 @default.
• W2034646721 hasConcept C126322002 @default.
• W2034646721 hasConcept C135763542 @default.
• W2034646721 hasConcept C146403970 @default.
• W2034646721 hasConcept C164705383 @default.
• W2034646721 hasConcept C185263204 @default.
• W2034646721 hasConcept C2779362680 @default.
• W2034646721 hasConcept C2779703243 @default.
• W2034646721 hasConcept C54355233 @default.
• W2034646721 hasConcept C71924100 @default.
• W2034646721 hasConcept C83743174 @default.
• W2034646721 hasConcept C86803240 @default.
• W2034646721 hasConceptScore W2034646721C104317684 @default.
• W2034646721 hasConceptScore W2034646721C118441451 @default.
• W2034646721 hasConceptScore W2034646721C126322002 @default.
• W2034646721 hasConceptScore W2034646721C135763542 @default.
• W2034646721 hasConceptScore W2034646721C146403970 @default.
• W2034646721 hasConceptScore W2034646721C164705383 @default.
• W2034646721 hasConceptScore W2034646721C185263204 @default.
• W2034646721 hasConceptScore W2034646721C2779362680 @default.
• W2034646721 hasConceptScore W2034646721C2779703243 @default.
• W2034646721 hasConceptScore W2034646721C54355233 @default.
• W2034646721 hasConceptScore W2034646721C71924100 @default.
• W2034646721 hasConceptScore W2034646721C83743174 @default.
• W2034646721 hasConceptScore W2034646721C86803240 @default.
• W2034646721 hasIssue "3" @default.
• W2034646721 hasLocation W20346467211 @default.
• W2034646721 hasLocation W20346467212 @default.
• W2034646721 hasOpenAccess W2034646721 @default.
• W2034646721 hasPrimaryLocation W20346467211 @default.
• W2034646721 hasRelatedWork W1559293525 @default.

• next