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• W2034646895 abstract "Efforts to unravel the mechanisms underlying taste sensation (gustation) have largely focused on rodents. Here we present the first comprehensive characterization of gene expression in primate taste buds. Our findings reveal unique new insights into the biology of taste buds. We generated a taste bud gene expression database using laser capture microdissection (LCM) procured fungiform (FG) and circumvallate (CV) taste buds from primates. We also used LCM to collect the top and bottom portions of CV taste buds. Affymetrix genome wide arrays were used to analyze gene expression in all samples. Known taste receptors are preferentially expressed in the top portion of taste buds. Genes associated with the cell cycle and stem cells are preferentially expressed in the bottom portion of taste buds, suggesting that precursor cells are located there. Several chemokines including CXCL14 and CXCL8 are among the highest expressed genes in taste buds, indicating that immune system related processes are active in taste buds. Several genes expressed specifically in endocrine glands including growth hormone releasing hormone and its receptor are also strongly expressed in taste buds, suggesting a link between metabolism and taste. Cell type-specific expression of transcription factors and signaling molecules involved in cell fate, including KIT, reveals the taste bud as an active site of cell regeneration, differentiation, and development. IKBKAP, a gene mutated in familial dysautonomia, a disease that results in loss of taste buds, is expressed in taste cells that communicate with afferent nerve fibers via synaptic transmission. This database highlights the power of LCM coupled with transcriptional profiling to dissect the molecular composition of normal tissues, represents the most comprehensive molecular analysis of primate taste buds to date, and provides a foundation for further studies in diverse aspects of taste biology." @default.
• W2034646895 created "2016-06-24" @default.
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• W2034646895 date "2009-07-28" @default.
• W2034646895 modified "2023-10-01" @default.
• W2034646895 title "Genome-Wide Analysis of Gene Expression in Primate Taste Buds Reveals Links to Diverse Processes" @default.
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• W2034646895 cites W1967237601 @default.
• W2034646895 cites W1968552568 @default.
• W2034646895 cites W1971581466 @default.
• W2034646895 cites W1982215719 @default.
• W2034646895 cites W1984031781 @default.
• W2034646895 cites W1989717470 @default.
• W2034646895 cites W1989861660 @default.
• W2034646895 cites W1994929488 @default.
• W2034646895 cites W2002701489 @default.
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• W2034646895 cites W2011717046 @default.
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• W2034646895 cites W2023115254 @default.
• W2034646895 cites W2025369249 @default.
• W2034646895 cites W2027830931 @default.
• W2034646895 cites W2028284319 @default.
• W2034646895 cites W2030294496 @default.
• W2034646895 cites W2033990615 @default.
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• W2034646895 cites W2035906353 @default.
• W2034646895 cites W2038510532 @default.
• W2034646895 cites W2038573621 @default.
• W2034646895 cites W2040531711 @default.
• W2034646895 cites W2042351431 @default.
• W2034646895 cites W2043929216 @default.
• W2034646895 cites W2046337543 @default.
• W2034646895 cites W2047120515 @default.
• W2034646895 cites W2047660785 @default.
• W2034646895 cites W2048045088 @default.
• W2034646895 cites W2050552377 @default.
• W2034646895 cites W2051588335 @default.
• W2034646895 cites W2052654641 @default.
• W2034646895 cites W2053690380 @default.
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• W2034646895 cites W2056568186 @default.
• W2034646895 cites W2056916657 @default.
• W2034646895 cites W2059204710 @default.
• W2034646895 cites W2061018632 @default.
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• W2034646895 cites W2062681374 @default.
• W2034646895 cites W2065387006 @default.
• W2034646895 cites W2073189307 @default.
• W2034646895 cites W2074415344 @default.
• W2034646895 cites W2075198876 @default.
• W2034646895 cites W2075956684 @default.
• W2034646895 cites W2076924133 @default.
• W2034646895 cites W2077185686 @default.
• W2034646895 cites W2085600539 @default.
• W2034646895 cites W2085825273 @default.
• W2034646895 cites W2089885047 @default.
• W2034646895 cites W2092908962 @default.
• W2034646895 cites W2098744504 @default.
• W2034646895 cites W2114369243 @default.
• W2034646895 cites W2118548518 @default.
• W2034646895 cites W2120360916 @default.
• W2034646895 cites W2125548284 @default.
• W2034646895 cites W2135421977 @default.
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• W2034646895 doi "https://doi.org/10.1371/journal.pone.0006395" @default.
• W2034646895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2712080" @default.
• W2034646895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19636377" @default.
• W2034646895 hasPublicationYear "2009" @default.
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