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• W2034647542 abstract "<h2>Abstract</h2> Twenty patients with infantile spasms were treated with high doses of vitamin B₆, valproic acid, or both. Three of 13 patients (23%) treated initially with high doses of vitamin B₆ demonstrated a definite reduction in seizures; 2 patients had no improvement on electroencephalography. Vitamin B₆ therapy alone was continued in a single patient (8%) who remained seizure-free during the 15-month follow-up period. Initial treatment with vitamin B₆ and valproic acid improved the electroencephalogram significantly more (<i>P</i> < 0.05) than initial vitamin B₆ treatment alone. The group which had valproic acid added to vitamin B₆ therapy had significantly fewer seizures (<i>P</i> < 0.05) and better electroencephalograms (<i>P</i> < 0.01) than did the group treated initially with vitamin B₆ alone. There were no significant differences among the group treated initially with vitamin B₆, the group treated initially with valproic acid, and the group in which valproic acid was substituted for vitamin B₆. ACTH was more effective in abolishing seizures than was valproic acid or vitamin B₆ and valproic acid. ACTH had an excellent effect on seizures in 86% of patients who did not respond well to vitamin B₆, valproic acid, or both; however, many of these patients had later recurrence of infantile spasms. The combination of vitamin B₆ and valproic acid is effective and safe in the treatment of infantile spasms." @default.
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• W2034647542 date "1991-03-01" @default.
• W2034647542 modified "2023-09-25" @default.
• W2034647542 title "Vitamin B6 and valproic acid in treatment of infantile spasms" @default.
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• W2034647542 doi "https://doi.org/10.1016/0887-8994(91)90003-4" @default.
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