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- W2034648844 abstract "The transcription factor E2A controls the initiation of B lymphopoiesis, which is arrested at the pre-pro-B cell stage in E2A-deficient mice. Here, we demonstrate by conditional mutagenesis that E2A is essential for the development of pro-B, pre-B, and immature B cells in the bone marrow. E2A is, however, dispensable for the generation of mature B cells and plasma cells in peripheral lymphoid organs. In contrast, germinal center B cell development is impaired in the absence of E2A despite normal AID expression and class-switch recombination. Molecular analysis revealed that E2A is required not only for initiating but also for maintaining the expression of Ebf1, Pax5, and the B cell gene program in pro-B cells. Notably, precocious Pax5 transcription from the Ikzf1 locus promotes pro-B cell development in E2A-deficient mice, demonstrating that ectopic Pax5 expression is sufficient to activate the B lymphoid transcription program in vivo in the absence of E2A." @default.
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- W2034648844 date "2008-06-01" @default.
- W2034648844 modified "2023-10-05" @default.
- W2034648844 title "Instructive Role of the Transcription Factor E2A in Early B Lymphopoiesis and Germinal Center B Cell Development" @default.
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- W2034648844 doi "https://doi.org/10.1016/j.immuni.2008.04.014" @default.
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