FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034649150> ?p ?o ?g. }

• W2034649150 endingPage "e13927" @default.
• W2034649150 startingPage "e13927" @default.
• W2034649150 abstract "Type I interferons (IFNs) function as the first line of defense against viral infections by modulating cell growth, establishing an antiviral state and influencing the activation of various immune cells. Viruses such as influenza have developed mechanisms to evade this defense mechanism and during infection with influenza A viruses, the non-structural protein 1 (NS1) encoded by the virus genome suppresses induction of IFNs-α/β. Here we show that expression of avian H5N1 NS1 in HeLa cells leads to a block in IFN signaling. H5N1 NS1 reduces IFN-inducible tyrosine phosphorylation of STAT1, STAT2 and STAT3 and inhibits the nuclear translocation of phospho-STAT2 and the formation of IFN-inducible STAT1:1-, STAT1:3- and STAT3:3- DNA complexes. Inhibition of IFN-inducible STAT signaling by NS1 in HeLa cells is, in part, a consequence of NS1-mediated inhibition of expression of the IFN receptor subunit, IFNAR1. In support of this NS1-mediated inhibition, we observed a reduction in expression of ifnar1 in ex vivo human non-tumor lung tissues infected with H5N1 and H1N1 viruses. Moreover, H1N1 and H5N1 virus infection of human monocyte-derived macrophages led to inhibition of both ifnar1 and ifnar2 expression. In addition, NS1 expression induces up-regulation of the JAK/STAT inhibitors, SOCS1 and SOCS3. By contrast, treatment of ex vivo human lung tissues with IFN-α results in the up-regulation of a number of IFN-stimulated genes and inhibits both H5N1 and H1N1 virus replication. The data suggest that NS1 can directly interfere with IFN signaling to enhance viral replication, but that treatment with IFN can nevertheless override these inhibitory effects to block H5N1 and H1N1 virus infections." @default.
• W2034649150 created "2016-06-24" @default.
• W2034649150 creator A5024050485 @default.
• W2034649150 creator A5034880731 @default.
• W2034649150 creator A5046056065 @default.
• W2034649150 creator A5056354202 @default.
• W2034649150 creator A5059344072 @default.
• W2034649150 creator A5062630753 @default.
• W2034649150 creator A5063013099 @default.
• W2034649150 creator A5065661973 @default.
• W2034649150 creator A5076213121 @default.
• W2034649150 creator A5085109943 @default.
• W2034649150 creator A5089372773 @default.
• W2034649150 date "2010-11-10" @default.
• W2034649150 modified "2023-10-16" @default.
• W2034649150 title "Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling" @default.
• W2034649150 cites W1484061442 @default.
• W2034649150 cites W1823844324 @default.
• W2034649150 cites W1964466523 @default.
• W2034649150 cites W1968134447 @default.
• W2034649150 cites W1974130697 @default.
• W2034649150 cites W1976382957 @default.
• W2034649150 cites W1977365050 @default.
• W2034649150 cites W1977457931 @default.
• W2034649150 cites W1990167513 @default.
• W2034649150 cites W1991297120 @default.
• W2034649150 cites W1991865146 @default.
• W2034649150 cites W2003926950 @default.
• W2034649150 cites W2004593694 @default.
• W2034649150 cites W2008332711 @default.
• W2034649150 cites W2009127910 @default.
• W2034649150 cites W2014731361 @default.
• W2034649150 cites W2017309788 @default.
• W2034649150 cites W2020464368 @default.
• W2034649150 cites W2021338588 @default.
• W2034649150 cites W2021827364 @default.
• W2034649150 cites W2029010559 @default.
• W2034649150 cites W2033843609 @default.
• W2034649150 cites W2035268935 @default.
• W2034649150 cites W2038698914 @default.
• W2034649150 cites W2050361028 @default.
• W2034649150 cites W2056107229 @default.
• W2034649150 cites W2056732680 @default.
• W2034649150 cites W2062311162 @default.
• W2034649150 cites W2063249691 @default.
• W2034649150 cites W2065631534 @default.
• W2034649150 cites W2079309377 @default.
• W2034649150 cites W2079357798 @default.
• W2034649150 cites W2084742492 @default.
• W2034649150 cites W2090002359 @default.
• W2034649150 cites W2094896478 @default.
• W2034649150 cites W2096313549 @default.
• W2034649150 cites W2104397822 @default.
• W2034649150 cites W2105121982 @default.
• W2034649150 cites W2108486371 @default.
• W2034649150 cites W2109593713 @default.
• W2034649150 cites W2110214166 @default.
• W2034649150 cites W2112360308 @default.
• W2034649150 cites W2112901090 @default.
• W2034649150 cites W2117200691 @default.
• W2034649150 cites W2119257614 @default.
• W2034649150 cites W2122988122 @default.
• W2034649150 cites W2126303830 @default.
• W2034649150 cites W2128338457 @default.
• W2034649150 cites W2132148594 @default.
• W2034649150 cites W2138468856 @default.
• W2034649150 cites W2144681562 @default.
• W2034649150 cites W2150658610 @default.
• W2034649150 cites W2152283024 @default.
• W2034649150 cites W2155470315 @default.
• W2034649150 cites W2160898409 @default.
• W2034649150 cites W2163853272 @default.
• W2034649150 cites W2165702171 @default.
• W2034649150 cites W2166917491 @default.
• W2034649150 cites W2167915597 @default.
• W2034649150 doi "https://doi.org/10.1371/journal.pone.0013927" @default.
• W2034649150 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2978095" @default.
• W2034649150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21085662" @default.
• W2034649150 hasPublicationYear "2010" @default.
• W2034649150 type Work @default.
• W2034649150 sameAs 2034649150 @default.
• W2034649150 citedByCount "142" @default.
• W2034649150 countsByYear W20346491502012 @default.
• W2034649150 countsByYear W20346491502013 @default.
• W2034649150 countsByYear W20346491502014 @default.
• W2034649150 countsByYear W20346491502015 @default.
• W2034649150 countsByYear W20346491502016 @default.
• W2034649150 countsByYear W20346491502017 @default.
• W2034649150 countsByYear W20346491502018 @default.
• W2034649150 countsByYear W20346491502019 @default.
• W2034649150 countsByYear W20346491502020 @default.
• W2034649150 countsByYear W20346491502021 @default.
• W2034649150 countsByYear W20346491502022 @default.
• W2034649150 countsByYear W20346491502023 @default.
• W2034649150 crossrefType "journal-article" @default.
• W2034649150 hasAuthorship W2034649150A5024050485 @default.
• W2034649150 hasAuthorship W2034649150A5034880731 @default.
• W2034649150 hasAuthorship W2034649150A5046056065 @default.

• next