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- W2034649260 abstract "Pathogens must steal iron from their hosts to establish infection. In mammals, hemoglobin (Hb) represents the largest reservoir of iron, and pathogens express Hb-binding proteins to access this source. Here, we show how one of the commonest and most significant human pathogens, Staphylococcus aureus, captures Hb as the first step of an iron-scavenging pathway. The x-ray crystal structure of Hb bound to a domain from the Isd (iron-regulated surface determinant) protein, IsdH, is the first structure of a Hb capture complex to be determined. Surface mutations in Hb that reduce binding to the Hb-receptor limit the capacity of S. aureus to utilize Hb as an iron source, suggesting that Hb sequence is a factor in host susceptibility to infection. The demonstration that pathogens make highly specific recognition complexes with Hb raises the possibility of developing inhibitors of Hb binding as antibacterial agents." @default.
- W2034649260 created "2016-06-24" @default.
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- W2034649260 date "2011-11-01" @default.
- W2034649260 modified "2023-10-16" @default.
- W2034649260 title "Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH" @default.
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- W2034649260 cites W1979135961 @default.
- W2034649260 cites W1979194107 @default.
- W2034649260 cites W1980448333 @default.
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- W2034649260 cites W2011450595 @default.
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- W2034649260 cites W2025766479 @default.
- W2034649260 cites W2028606746 @default.
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- W2034649260 cites W2144081223 @default.
- W2034649260 cites W2148947898 @default.
- W2034649260 cites W2149132779 @default.
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- W2034649260 doi "https://doi.org/10.1074/jbc.m111.287300" @default.
- W2034649260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3207429" @default.
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- W2034649260 hasPublicationYear "2011" @default.
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