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- W203464949 abstract "This chapter discusses a study analyzing operation of two epinephrine receptors and an acetylcholine receptor in the exocrine cell of the rat parotid gland. The β- and the α-adrenergic responses in rat parotid slices were examined in some detail with special reference to their interrelationship within the same cell. Activation of the β-receptor caused formation of cyclic AMP which in turn brought about a transformation of the secretory granule into an amoeba-like structure. The pseudopodia of the activated secretory granule fused with the cell membrane facing the acinar lumen and the content of the granule was thus placed outside the cell. More than 80% of the total amylase in the slices was secreted within 90 min provided that simultaneous activation of the α-receptor was prevented. This could be achieved by a variety of means, induction of enzyme secretion by isoproterenol which activates only the β-receptor, or induction by epinephrine but in the absence of added Ca2+. The findings suggest that when epinephrine activates simultaneously α- and β-receptors within the same cell, it opens two completely independent pathways of response." @default.
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- W203464949 date "1973-01-01" @default.
- W203464949 modified "2023-09-23" @default.
- W203464949 title "OPERATION OF TWO EPINEPHRINE RECEPTORS AND AN ACETYLCHOLINE RECEPTOR IN THE EXOCRINE CELL OF THE RAT PAROTID GLAND" @default.
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- W203464949 doi "https://doi.org/10.1016/b978-0-08-017922-3.50066-6" @default.
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