FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034650096> ?p ?o ?g. }

• W2034650096 endingPage "842" @default.
• W2034650096 startingPage "834" @default.
• W2034650096 abstract "Administration of fibroblast growth factor (FGF)-2 for 2 weeks induces a successful cartilaginous repair response in 5-mm full-thickness articular cartilage defects in rabbits. The purpose of this study was to investigate the effects of a short time exposure to FGF-2 on the repair of the defects.Five-mm-diameter cylindrical defects, which do not repair spontaneously, were created in the femoral trochlea of the rabbit knees. The defects were administered sterile saline or FGF-2 (150pg/h) via an osmotic pump for the initial 1 day, 3 days, or 2 weeks, and we assessed the FGF-2 action on the proliferation and migration of mesenchymal cells in the reparative tissue. Using a total of 126 rabbits, we performed three sets of experiments. We also studied the effect of FGF-2 on migration of marrow-derived mesenchymal cells in vitro.FGF-2 treatment for 1 day or 3 days induced the sequential chondrogenic repair responses that led to successful cartilaginous resurfacing of defects within 8 weeks as well as the 2-week treatment did. We confirmed by a radioisotope study that FGF-2 injected was rapidly eliminated from the defects (a residual ratio of 50% within 30min). The effect of FGF-2 on cultured marrow-derived cells suggested that FGF-2 facilitated the mobilization and migration of replicating mesenchymal cells from bone marrow.Only 1 day exposure to FGF-2 is sufficient for induction of the chondrogenic repair response in 5-mm-diameter full-thickness defects of articular cartilage in rabbits. FGF-2 stimulated the recruitment of mesenchymal cells into the defects, which was a limiting step for the induction of cartilage." @default.
• W2034650096 created "2016-06-24" @default.
• W2034650096 creator A5012434600 @default.
• W2034650096 creator A5053228636 @default.
• W2034650096 creator A5066304083 @default.
• W2034650096 creator A5088090749 @default.
• W2034650096 creator A5089926644 @default.
• W2034650096 date "2004-10-01" @default.
• W2034650096 modified "2023-10-18" @default.
• W2034650096 title "One day exposure to FGF-2 was sufficient for the regenerative repair of full-thickness defects of articular cartilage in rabbits" @default.
• W2034650096 cites W1522229466 @default.
• W2034650096 cites W1948689584 @default.
• W2034650096 cites W1980731745 @default.
• W2034650096 cites W1982534962 @default.
• W2034650096 cites W2002267044 @default.
• W2034650096 cites W2006470458 @default.
• W2034650096 cites W2007821628 @default.
• W2034650096 cites W2010901408 @default.
• W2034650096 cites W2015832973 @default.
• W2034650096 cites W2017786515 @default.
• W2034650096 cites W2021345772 @default.
• W2034650096 cites W2023254380 @default.
• W2034650096 cites W2027932074 @default.
• W2034650096 cites W2029075071 @default.
• W2034650096 cites W2031504305 @default.
• W2034650096 cites W2031951869 @default.
• W2034650096 cites W2040162459 @default.
• W2034650096 cites W2049521062 @default.
• W2034650096 cites W2053502776 @default.
• W2034650096 cites W2053675422 @default.
• W2034650096 cites W2055513799 @default.
• W2034650096 cites W2060338007 @default.
• W2034650096 cites W2073078971 @default.
• W2034650096 cites W2073105936 @default.
• W2034650096 cites W2073690170 @default.
• W2034650096 cites W2074473202 @default.
• W2034650096 cites W2083691229 @default.
• W2034650096 cites W2100562749 @default.
• W2034650096 cites W2116947669 @default.
• W2034650096 cites W2129332981 @default.
• W2034650096 cites W2131454256 @default.
• W2034650096 cites W2133685524 @default.
• W2034650096 cites W2134709004 @default.
• W2034650096 cites W2137320484 @default.
• W2034650096 cites W2151273918 @default.
• W2034650096 cites W2159999899 @default.
• W2034650096 cites W2163976338 @default.
• W2034650096 cites W2165181073 @default.
• W2034650096 cites W2281256922 @default.
• W2034650096 cites W4234559173 @default.
• W2034650096 doi "https://doi.org/10.1016/j.joca.2004.07.003" @default.
• W2034650096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15450534" @default.
• W2034650096 hasPublicationYear "2004" @default.
• W2034650096 type Work @default.
• W2034650096 sameAs 2034650096 @default.
• W2034650096 citedByCount "65" @default.
• W2034650096 countsByYear W20346500962012 @default.
• W2034650096 countsByYear W20346500962013 @default.
• W2034650096 countsByYear W20346500962015 @default.
• W2034650096 countsByYear W20346500962016 @default.
• W2034650096 countsByYear W20346500962017 @default.
• W2034650096 countsByYear W20346500962018 @default.
• W2034650096 countsByYear W20346500962019 @default.
• W2034650096 countsByYear W20346500962020 @default.
• W2034650096 countsByYear W20346500962021 @default.
• W2034650096 countsByYear W20346500962022 @default.
• W2034650096 countsByYear W20346500962023 @default.
• W2034650096 crossrefType "journal-article" @default.
• W2034650096 hasAuthorship W2034650096A5012434600 @default.
• W2034650096 hasAuthorship W2034650096A5053228636 @default.
• W2034650096 hasAuthorship W2034650096A5066304083 @default.
• W2034650096 hasAuthorship W2034650096A5088090749 @default.
• W2034650096 hasAuthorship W2034650096A5089926644 @default.
• W2034650096 hasBestOaLocation W20346500961 @default.
• W2034650096 hasConcept C105702510 @default.
• W2034650096 hasConcept C126322002 @default.
• W2034650096 hasConcept C141071460 @default.
• W2034650096 hasConcept C142724271 @default.
• W2034650096 hasConcept C16685009 @default.
• W2034650096 hasConcept C170493617 @default.
• W2034650096 hasConcept C171056886 @default.
• W2034650096 hasConcept C198826908 @default.
• W2034650096 hasConcept C2780007613 @default.
• W2034650096 hasConcept C2780550940 @default.
• W2034650096 hasConcept C35496256 @default.
• W2034650096 hasConcept C71924100 @default.
• W2034650096 hasConcept C74373430 @default.
• W2034650096 hasConcept C86803240 @default.
• W2034650096 hasConcept C95444343 @default.
• W2034650096 hasConceptScore W2034650096C105702510 @default.
• W2034650096 hasConceptScore W2034650096C126322002 @default.
• W2034650096 hasConceptScore W2034650096C141071460 @default.
• W2034650096 hasConceptScore W2034650096C142724271 @default.
• W2034650096 hasConceptScore W2034650096C16685009 @default.
• W2034650096 hasConceptScore W2034650096C170493617 @default.
• W2034650096 hasConceptScore W2034650096C171056886 @default.
• W2034650096 hasConceptScore W2034650096C198826908 @default.
• W2034650096 hasConceptScore W2034650096C2780007613 @default.

• next