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• W2034650820 abstract "The anticonvulsant activity of N-[beta-[4-beta-phenylethyl)phenyl]-beta-hydroxyethyl]-imidazole hydrochloride, denzimol, was studied following intraperitoneal administration in DBA/2 mice (seizures induced by sound). Protection against sound-induced seizures was observed after intraperitoneal administration of denzimol (3-15 mg/kg). The ED50 values for the suppression of tonic, clonic and wild running phases of sound-induced seizures were 1.24, 2.61 and 6.03 mg/kg, respectively. This protective action was significantly reduced by pretreatment with aminophylline (25 mg/kg i.p.), CGS 8216 (1 or 5 mg/kg i.p.) and Ro 15-1788 (2.5 mg/kg i.p). The present experiments suggest an involvement of purinergic and benzodiazepine mechanisms in the anticonvulsant action of denzimol." @default.
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• W2034650820 date "1987-09-01" @default.
• W2034650820 modified "2023-10-15" @default.
• W2034650820 title "Anticonvulsant effect of denzimolin DBA/2 mice" @default.
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• W2034650820 doi "https://doi.org/10.1016/0028-3908(87)90109-2" @default.
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