Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034652209> ?p ?o ?g. }
- W2034652209 abstract "Amphibians possess beneficial skin bacteria that protect against the disease chytridiomycosis by producing secondary metabolites that inhibit the pathogen Batrachochytrium dendrobatidis (Bd). Metabolite production may be a mechanism of competition between bacterial species that results in host protection as a by-product. We expect that some co-cultures of bacterial species or strains will result in greater Bd inhibition than mono-cultures. To test this, we cultured four bacterial isolates (Bacillus sp., Janthinobacterium sp., Pseudomonas sp. and Chitinophaga arvensicola) from red-backed salamanders (Plethodon cinereus) and cultured isolates both alone and together to collect their cell-free supernatants (CFS). We challenged Bd with CFSs from four bacterial species in varying combinations. This resulted in three experimental treatments: (1) CFSs of single isolates; (2) combined CFSs of two isolates; and (3) CFSs from co-cultures. Pair-wise combinations of four bacterial isolates CFSs were assayed against Bd and revealed additive Bd inhibition in 42.2% of trials, synergistic inhibition in 42.2% and no effect in 16.6% of trials. When bacteria isolates were grown in co-cultures, complete Bd inhibition was generally observed, and synergistic inhibition occurred in four out of six trials. A metabolite profile of the most potent co-culture, Bacillus sp. and Chitinophaga arvensicola, was determined with LC-MS and compared with the profiles of each isolate in mono-culture. Emergent metabolites appearing in the co-culture were inhibitory to Bd, and the most potent inhibitor was identified as tryptophol. Thus mono-cultures of bacteria cultured from red-backed salamanders interacted synergistically and additively to inhibit Bd, and such bacteria produced emergent metabolites when cultured together, with even greater pathogen inhibition. Knowledge of how bacterial species interact to inhibit Bd can be used to select probiotics to provide amphibians with protection against Bd." @default.
- W2034652209 created "2016-06-24" @default.
- W2034652209 creator A5007099796 @default.
- W2034652209 creator A5039131935 @default.
- W2034652209 creator A5048122236 @default.
- W2034652209 creator A5060892195 @default.
- W2034652209 creator A5066258704 @default.
- W2034652209 creator A5088835744 @default.
- W2034652209 date "2014-08-21" @default.
- W2034652209 modified "2023-10-13" @default.
- W2034652209 title "Interactions between amphibians' symbiotic bacteria cause the production of emergent anti-fungal metabolites" @default.
- W2034652209 cites W1835464617 @default.
- W2034652209 cites W1967912997 @default.
- W2034652209 cites W1969037718 @default.
- W2034652209 cites W1974030188 @default.
- W2034652209 cites W1978412177 @default.
- W2034652209 cites W1991565970 @default.
- W2034652209 cites W1994542148 @default.
- W2034652209 cites W2009341256 @default.
- W2034652209 cites W2011920234 @default.
- W2034652209 cites W2013911852 @default.
- W2034652209 cites W2036922924 @default.
- W2034652209 cites W2042562061 @default.
- W2034652209 cites W2049085830 @default.
- W2034652209 cites W2054449096 @default.
- W2034652209 cites W2060063072 @default.
- W2034652209 cites W2076433636 @default.
- W2034652209 cites W2078835248 @default.
- W2034652209 cites W2087553447 @default.
- W2034652209 cites W2108552041 @default.
- W2034652209 cites W2111760270 @default.
- W2034652209 cites W2127647479 @default.
- W2034652209 cites W2128236594 @default.
- W2034652209 cites W2130378728 @default.
- W2034652209 cites W2144149632 @default.
- W2034652209 cites W2154337567 @default.
- W2034652209 cites W2155047750 @default.
- W2034652209 cites W2159376422 @default.
- W2034652209 cites W2160571481 @default.
- W2034652209 cites W2171605634 @default.
- W2034652209 cites W2180338086 @default.
- W2034652209 cites W2617270611 @default.
- W2034652209 cites W320186974 @default.
- W2034652209 doi "https://doi.org/10.3389/fmicb.2014.00441" @default.
- W2034652209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4139739" @default.
- W2034652209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25191317" @default.
- W2034652209 hasPublicationYear "2014" @default.
- W2034652209 type Work @default.
- W2034652209 sameAs 2034652209 @default.
- W2034652209 citedByCount "93" @default.
- W2034652209 countsByYear W20346522092015 @default.
- W2034652209 countsByYear W20346522092016 @default.
- W2034652209 countsByYear W20346522092017 @default.
- W2034652209 countsByYear W20346522092018 @default.
- W2034652209 countsByYear W20346522092019 @default.
- W2034652209 countsByYear W20346522092020 @default.
- W2034652209 countsByYear W20346522092021 @default.
- W2034652209 countsByYear W20346522092022 @default.
- W2034652209 countsByYear W20346522092023 @default.
- W2034652209 crossrefType "journal-article" @default.
- W2034652209 hasAuthorship W2034652209A5007099796 @default.
- W2034652209 hasAuthorship W2034652209A5039131935 @default.
- W2034652209 hasAuthorship W2034652209A5048122236 @default.
- W2034652209 hasAuthorship W2034652209A5060892195 @default.
- W2034652209 hasAuthorship W2034652209A5066258704 @default.
- W2034652209 hasAuthorship W2034652209A5088835744 @default.
- W2034652209 hasBestOaLocation W20346522091 @default.
- W2034652209 hasConcept C104317684 @default.
- W2034652209 hasConcept C2776460866 @default.
- W2034652209 hasConcept C2777347573 @default.
- W2034652209 hasConcept C2777477808 @default.
- W2034652209 hasConcept C2781463711 @default.
- W2034652209 hasConcept C523546767 @default.
- W2034652209 hasConcept C54355233 @default.
- W2034652209 hasConcept C55493867 @default.
- W2034652209 hasConcept C86803240 @default.
- W2034652209 hasConcept C89423630 @default.
- W2034652209 hasConceptScore W2034652209C104317684 @default.
- W2034652209 hasConceptScore W2034652209C2776460866 @default.
- W2034652209 hasConceptScore W2034652209C2777347573 @default.
- W2034652209 hasConceptScore W2034652209C2777477808 @default.
- W2034652209 hasConceptScore W2034652209C2781463711 @default.
- W2034652209 hasConceptScore W2034652209C523546767 @default.
- W2034652209 hasConceptScore W2034652209C54355233 @default.
- W2034652209 hasConceptScore W2034652209C55493867 @default.
- W2034652209 hasConceptScore W2034652209C86803240 @default.
- W2034652209 hasConceptScore W2034652209C89423630 @default.
- W2034652209 hasLocation W20346522091 @default.
- W2034652209 hasLocation W20346522092 @default.
- W2034652209 hasLocation W20346522093 @default.
- W2034652209 hasLocation W20346522094 @default.
- W2034652209 hasLocation W20346522095 @default.
- W2034652209 hasOpenAccess W2034652209 @default.
- W2034652209 hasPrimaryLocation W20346522091 @default.
- W2034652209 hasRelatedWork W108004249 @default.
- W2034652209 hasRelatedWork W112259923 @default.
- W2034652209 hasRelatedWork W1171361647 @default.
- W2034652209 hasRelatedWork W1502217983 @default.
- W2034652209 hasRelatedWork W1846339391 @default.
- W2034652209 hasRelatedWork W1980876687 @default.