Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034653559> ?p ?o ?g. }
- W2034653559 endingPage "42619" @default.
- W2034653559 startingPage "42611" @default.
- W2034653559 abstract "SUMOylation occurs predominantly in the nucleus, but non-nuclear proteins can also be SUMOylated. It is unclear how intracellular trafficking of the SUMOylation enzymes is regulated to catalyze SUMOylation in different cellular compartments. Here we report that the SAE2 subunit of human SUMO activation enzyme (SAE) underwent rapid nucleocytoplasmic shuttling and its nuclear accumulation depended on SUMO modification at the C terminus. The SUMOylation sites included three Lys residues on the bipartite nuclear localization sequence (NLS) and two Lys residues outside of but adjacent to the NLS, and their SUMOylation was catalyzed by Ubc9. Because SAE2 forms a tight heterodimer with SAE1 and it controls the trafficking of the heterodimer, this study has identified the mechanism used to localize SAE to the nucleus. Similar mechanisms are likely to exist for other proteins that depend on SUMOylation for nuclear localization. SUMOylation occurs predominantly in the nucleus, but non-nuclear proteins can also be SUMOylated. It is unclear how intracellular trafficking of the SUMOylation enzymes is regulated to catalyze SUMOylation in different cellular compartments. Here we report that the SAE2 subunit of human SUMO activation enzyme (SAE) underwent rapid nucleocytoplasmic shuttling and its nuclear accumulation depended on SUMO modification at the C terminus. The SUMOylation sites included three Lys residues on the bipartite nuclear localization sequence (NLS) and two Lys residues outside of but adjacent to the NLS, and their SUMOylation was catalyzed by Ubc9. Because SAE2 forms a tight heterodimer with SAE1 and it controls the trafficking of the heterodimer, this study has identified the mechanism used to localize SAE to the nucleus. Similar mechanisms are likely to exist for other proteins that depend on SUMOylation for nuclear localization." @default.
- W2034653559 created "2016-06-24" @default.
- W2034653559 creator A5009751070 @default.
- W2034653559 creator A5028354954 @default.
- W2034653559 creator A5036168031 @default.
- W2034653559 creator A5052134746 @default.
- W2034653559 date "2012-12-01" @default.
- W2034653559 modified "2023-10-16" @default.
- W2034653559 title "Sumoylation of SAE2 C Terminus Regulates SAE Nuclear Localization" @default.
- W2034653559 cites W1967707683 @default.
- W2034653559 cites W1967965392 @default.
- W2034653559 cites W1970061483 @default.
- W2034653559 cites W1971300341 @default.
- W2034653559 cites W1972890183 @default.
- W2034653559 cites W1973480232 @default.
- W2034653559 cites W1973731625 @default.
- W2034653559 cites W1979906352 @default.
- W2034653559 cites W1987129537 @default.
- W2034653559 cites W1987556650 @default.
- W2034653559 cites W1991189921 @default.
- W2034653559 cites W1992363628 @default.
- W2034653559 cites W1994218254 @default.
- W2034653559 cites W1996313023 @default.
- W2034653559 cites W1999054610 @default.
- W2034653559 cites W2006466204 @default.
- W2034653559 cites W2009442123 @default.
- W2034653559 cites W2009826707 @default.
- W2034653559 cites W2013108773 @default.
- W2034653559 cites W2016153572 @default.
- W2034653559 cites W2017284082 @default.
- W2034653559 cites W2027899041 @default.
- W2034653559 cites W2028638629 @default.
- W2034653559 cites W2032785100 @default.
- W2034653559 cites W2036331552 @default.
- W2034653559 cites W2044585322 @default.
- W2034653559 cites W2047134964 @default.
- W2034653559 cites W2067371211 @default.
- W2034653559 cites W2072798319 @default.
- W2034653559 cites W2073455176 @default.
- W2034653559 cites W2078232420 @default.
- W2034653559 cites W2087302056 @default.
- W2034653559 cites W2088357489 @default.
- W2034653559 cites W2090272354 @default.
- W2034653559 cites W2094134169 @default.
- W2034653559 cites W2098150321 @default.
- W2034653559 cites W2100200896 @default.
- W2034653559 cites W2104396972 @default.
- W2034653559 cites W2106162257 @default.
- W2034653559 cites W2110817748 @default.
- W2034653559 cites W2140562265 @default.
- W2034653559 cites W2145069182 @default.
- W2034653559 cites W2164801236 @default.
- W2034653559 cites W2169521652 @default.
- W2034653559 cites W2322149805 @default.
- W2034653559 cites W4256382461 @default.
- W2034653559 cites W95252060 @default.
- W2034653559 doi "https://doi.org/10.1074/jbc.m112.420877" @default.
- W2034653559 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3522262" @default.
- W2034653559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23095757" @default.
- W2034653559 hasPublicationYear "2012" @default.
- W2034653559 type Work @default.
- W2034653559 sameAs 2034653559 @default.
- W2034653559 citedByCount "40" @default.
- W2034653559 countsByYear W20346535592013 @default.
- W2034653559 countsByYear W20346535592014 @default.
- W2034653559 countsByYear W20346535592015 @default.
- W2034653559 countsByYear W20346535592016 @default.
- W2034653559 countsByYear W20346535592017 @default.
- W2034653559 countsByYear W20346535592018 @default.
- W2034653559 countsByYear W20346535592019 @default.
- W2034653559 countsByYear W20346535592020 @default.
- W2034653559 countsByYear W20346535592021 @default.
- W2034653559 countsByYear W20346535592022 @default.
- W2034653559 countsByYear W20346535592023 @default.
- W2034653559 crossrefType "journal-article" @default.
- W2034653559 hasAuthorship W2034653559A5009751070 @default.
- W2034653559 hasAuthorship W2034653559A5028354954 @default.
- W2034653559 hasAuthorship W2034653559A5036168031 @default.
- W2034653559 hasAuthorship W2034653559A5052134746 @default.
- W2034653559 hasBestOaLocation W20346535591 @default.
- W2034653559 hasConcept C104292427 @default.
- W2034653559 hasConcept C104317684 @default.
- W2034653559 hasConcept C144519050 @default.
- W2034653559 hasConcept C171350616 @default.
- W2034653559 hasConcept C185592680 @default.
- W2034653559 hasConcept C186435350 @default.
- W2034653559 hasConcept C25602115 @default.
- W2034653559 hasConcept C2780114586 @default.
- W2034653559 hasConcept C2780723820 @default.
- W2034653559 hasConcept C29512474 @default.
- W2034653559 hasConcept C49805395 @default.
- W2034653559 hasConcept C54757728 @default.
- W2034653559 hasConcept C55493867 @default.
- W2034653559 hasConcept C59157529 @default.
- W2034653559 hasConcept C86339819 @default.
- W2034653559 hasConcept C86803240 @default.
- W2034653559 hasConcept C95444343 @default.
- W2034653559 hasConceptScore W2034653559C104292427 @default.