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- W2034653698 abstract "Human seminal plasma is known to exhibit immunosuppressive activity in seminal plasma.The purpose was to characterize immunosuppressive proteins in seminal plasma.Gel filtration fractions of 100 to > 440 kDa were identified that inhibited DNA synthesis and killing activity of interleukin-2 stimulated lymphocytes.The fractions exhibiting immunosuppression also inhibited DNA synthesis in a mink lung cell bioassay commonly used to measure the activity for transforming growth factor beta (TGF-beta). The negative growth activity was diminished by a TGF-beta neutralizing monoclonal antibody. TGF-beta was further detected in the active fractions by Western immunoblot.These results identified TGF-beta as an immunosuppressive protein in human seminal plasma and may provide insight into the role of immunosuppression played by seminal plasma, such as in reproduction and neoplasia." @default.
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- W2034653698 date "1993-08-01" @default.
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- W2034653698 title "Transforming Growth Factor β as an Immunosuppressive Protein in Human Seminal Plasma" @default.
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- W2034653698 doi "https://doi.org/10.1111/j.1600-0897.1993.tb00594.x" @default.
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