Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034653971> ?p ?o ?g. }
- W2034653971 endingPage "241" @default.
- W2034653971 startingPage "234" @default.
- W2034653971 abstract "Although much is known about classic IFNγ inducers, little is known about the IFNγ inducing capability of inflammasome-activated monocytes. In this study, supernatants from LPS/ATP-stimulated human monocytes were analyzed for their ability to induce IFNγ production by KG-1 cells. Unexpectedly, monocyte-derived IFN inducing activity was detected, but it was completely inhibited by IL-1β, not IL-18 blockade. Moreover, size-fractionation of the monocyte conditioned media dramatically reduced the IFNγ inducing activity of IL-1β, suggesting that IL-1β requires a cofactor to induce IFNγ production in KG-1 cells. Because TNFα is known to synergize with IL-1β for various gene products, it was studied as the putative IL-1β synergizing factor. Although recombinant TNFα (rTNFα) alone had no IFNγ inducing activity, neutralization of TNFα in the monocyte conditioned media inhibited the IFNγ inducing activity. Furthermore, rTNFα restored the IFNγ inducing activity of the size-fractionated IL-1β. Finally, rTNFα synergized with rIL-1β, as well as with rIL-1α and rIL-18, for KG-1 IFNγ release. These studies demonstrate a synergistic role between TNFα and IL-1 family members in the induction of IFNγ production and give caution to interpretations of KG-1 functional assays designed to detect functional IL-18." @default.
- W2034653971 created "2016-06-24" @default.
- W2034653971 creator A5007764317 @default.
- W2034653971 creator A5018443841 @default.
- W2034653971 creator A5019357352 @default.
- W2034653971 creator A5057789111 @default.
- W2034653971 creator A5091688364 @default.
- W2034653971 date "2008-11-01" @default.
- W2034653971 modified "2023-10-10" @default.
- W2034653971 title "A synergistic role for IL-1β and TNFα in monocyte-derived IFNγ inducing activity" @default.
- W2034653971 cites W1483162601 @default.
- W2034653971 cites W1529674879 @default.
- W2034653971 cites W1537817561 @default.
- W2034653971 cites W1559694381 @default.
- W2034653971 cites W1566117376 @default.
- W2034653971 cites W1576070276 @default.
- W2034653971 cites W1814850137 @default.
- W2034653971 cites W1921587687 @default.
- W2034653971 cites W1925502313 @default.
- W2034653971 cites W1963728385 @default.
- W2034653971 cites W1970506485 @default.
- W2034653971 cites W1971701051 @default.
- W2034653971 cites W1971853868 @default.
- W2034653971 cites W1972941078 @default.
- W2034653971 cites W1976367277 @default.
- W2034653971 cites W1980613104 @default.
- W2034653971 cites W1983321974 @default.
- W2034653971 cites W1987869706 @default.
- W2034653971 cites W1988563171 @default.
- W2034653971 cites W1988820544 @default.
- W2034653971 cites W1997573685 @default.
- W2034653971 cites W1997720968 @default.
- W2034653971 cites W2001588015 @default.
- W2034653971 cites W2010472128 @default.
- W2034653971 cites W2012494942 @default.
- W2034653971 cites W2012576192 @default.
- W2034653971 cites W2013068598 @default.
- W2034653971 cites W2018692535 @default.
- W2034653971 cites W2024171691 @default.
- W2034653971 cites W2034366668 @default.
- W2034653971 cites W2048117807 @default.
- W2034653971 cites W2050816432 @default.
- W2034653971 cites W2052240884 @default.
- W2034653971 cites W2054571187 @default.
- W2034653971 cites W2058852263 @default.
- W2034653971 cites W2059467769 @default.
- W2034653971 cites W2062075180 @default.
- W2034653971 cites W2090859543 @default.
- W2034653971 cites W2092918492 @default.
- W2034653971 cites W2095698281 @default.
- W2034653971 cites W2100701027 @default.
- W2034653971 cites W2105592913 @default.
- W2034653971 cites W2106196303 @default.
- W2034653971 cites W2108264583 @default.
- W2034653971 cites W2110600904 @default.
- W2034653971 cites W2118300904 @default.
- W2034653971 cites W2124650519 @default.
- W2034653971 cites W2125597028 @default.
- W2034653971 cites W2133263095 @default.
- W2034653971 cites W2134104734 @default.
- W2034653971 cites W2134735862 @default.
- W2034653971 cites W2149116091 @default.
- W2034653971 cites W2149673255 @default.
- W2034653971 cites W2152208529 @default.
- W2034653971 cites W2153279598 @default.
- W2034653971 cites W2162248918 @default.
- W2034653971 cites W2168115358 @default.
- W2034653971 cites W2208015810 @default.
- W2034653971 cites W2255616591 @default.
- W2034653971 cites W2402623008 @default.
- W2034653971 cites W3023923910 @default.
- W2034653971 cites W4211090967 @default.
- W2034653971 cites W4240978790 @default.
- W2034653971 cites W4248878742 @default.
- W2034653971 cites W4313306023 @default.
- W2034653971 cites W4313310005 @default.
- W2034653971 cites W4313342465 @default.
- W2034653971 cites W4313347828 @default.
- W2034653971 doi "https://doi.org/10.1016/j.cyto.2008.08.004" @default.
- W2034653971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2648511" @default.
- W2034653971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18805021" @default.
- W2034653971 hasPublicationYear "2008" @default.
- W2034653971 type Work @default.
- W2034653971 sameAs 2034653971 @default.
- W2034653971 citedByCount "18" @default.
- W2034653971 countsByYear W20346539712012 @default.
- W2034653971 countsByYear W20346539712013 @default.
- W2034653971 countsByYear W20346539712014 @default.
- W2034653971 countsByYear W20346539712015 @default.
- W2034653971 countsByYear W20346539712016 @default.
- W2034653971 countsByYear W20346539712018 @default.
- W2034653971 countsByYear W20346539712020 @default.
- W2034653971 countsByYear W20346539712022 @default.
- W2034653971 crossrefType "journal-article" @default.
- W2034653971 hasAuthorship W2034653971A5007764317 @default.
- W2034653971 hasAuthorship W2034653971A5018443841 @default.
- W2034653971 hasAuthorship W2034653971A5019357352 @default.
- W2034653971 hasAuthorship W2034653971A5057789111 @default.