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• W2034655982 startingPage "1071" @default.
• W2034655982 abstract "Mutation proI47A has recently been associated with lopinavir/ritonavir (LPV/r) resistance. Only four out of 1859 specimens (0.2%) sent for drug resistance testing (219 drug-naive and 1650 antiretroviral-experienced) showed I47A. All belonged to patients failing LPV/r. The prevalence among protease inhibitor-experienced patients was 0.6%. Phenotypic testing showed that proI47A caused high-level lopinavir resistance (> 100-fold) and cross-resistance to amprenavir, whereas it caused hypersusceptibility to saquinavir. ProI47A should thus be considered the primary lopinavir resistance mutation." @default.
• W2034655982 created "2016-06-24" @default.
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• W2034655982 date "2006-04-24" @default.
• W2034655982 modified "2023-09-25" @default.
• W2034655982 title "Prevalence of the HIV-1 protease mutation I47A in clinical practice and association with lopinavir resistance" @default.
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• W2034655982 doi "https://doi.org/10.1097/01.aids.0000222084.44411.cc" @default.
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