FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034656105> ?p ?o ?g. }

• W2034656105 endingPage "29" @default.
• W2034656105 startingPage "24" @default.
• W2034656105 abstract "The<i> Snail</i>-related zinc-finger transcription factor, <i>SLUG (SNAI2)</i>, is critical for the normal development of neural crest-derived cells and loss-of-function<i> SLUG</i> mutations have been proven to cause piebaldism and Waardenburg syndrome type 2 in a dose-dependent fashion. However, little is known about the consequences of <i>SLUG</i> overexpression in embryonic development. We report <i>SLUG</i> duplication in a child with a unique de novo 8q11.2→q13.3 duplication associated with tetralogy of Fallot, submucous cleft palate, renal anomalies, hypotonia and developmental delay. To investigate the effects of <i>Slug</i> overexpression on development, we analyzed mice carrying a <i>Slug</i> transgene. These mice were morphologically normal at birth, inferring that <i>Slug</i> overexpression is not sufficient to cause overt morphogenetic defects. In the adult mice, there was a 20% incidence of sudden death, cardiomegaly and cardiac failure associated with incipient mesenchymal tumorigenesis. These findings, while not directly implicating <i>Slug </i>in congenital and acquired heart disease, raise the possibility that <i>Slug</i> overexpression may contribute to specific cardiac phenotypes and cancer development." @default.
• W2034656105 created "2016-06-24" @default.
• W2034656105 creator A5013792120 @default.
• W2034656105 creator A5050182718 @default.
• W2034656105 creator A5053797819 @default.
• W2034656105 creator A5062228797 @default.
• W2034656105 creator A5063205640 @default.
• W2034656105 creator A5070749654 @default.
• W2034656105 creator A5071165719 @default.
• W2034656105 creator A5073028672 @default.
• W2034656105 creator A5075974674 @default.
• W2034656105 creator A5077566992 @default.
• W2034656105 creator A5080912506 @default.
• W2034656105 creator A5083222784 @default.
• W2034656105 date "2006-01-01" @default.
• W2034656105 modified "2023-10-16" @default.
• W2034656105 title "<i>SLUG (SNAI2)</i> overexpression in embryonic development" @default.
• W2034656105 cites W1970140424 @default.
• W2034656105 cites W1981114668 @default.
• W2034656105 cites W1986367824 @default.
• W2034656105 cites W2003149480 @default.
• W2034656105 cites W2006417453 @default.
• W2034656105 cites W2020333197 @default.
• W2034656105 cites W2023105205 @default.
• W2034656105 cites W2028036560 @default.
• W2034656105 cites W2033509429 @default.
• W2034656105 cites W2069603887 @default.
• W2034656105 cites W2075759604 @default.
• W2034656105 cites W2078933765 @default.
• W2034656105 cites W2087367170 @default.
• W2034656105 cites W2092710299 @default.
• W2034656105 cites W2137280750 @default.
• W2034656105 cites W2146445411 @default.
• W2034656105 cites W2148524869 @default.
• W2034656105 cites W2161537000 @default.
• W2034656105 cites W2165409131 @default.
• W2034656105 cites W2165901622 @default.
• W2034656105 cites W2167522637 @default.
• W2034656105 cites W35473498 @default.
• W2034656105 cites W4232633999 @default.
• W2034656105 doi "https://doi.org/10.1159/000091924" @default.
• W2034656105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16717446" @default.
• W2034656105 hasPublicationYear "2006" @default.
• W2034656105 type Work @default.
• W2034656105 sameAs 2034656105 @default.
• W2034656105 citedByCount "26" @default.
• W2034656105 countsByYear W20346561052012 @default.
• W2034656105 countsByYear W20346561052013 @default.
• W2034656105 countsByYear W20346561052014 @default.
• W2034656105 countsByYear W20346561052015 @default.
• W2034656105 countsByYear W20346561052016 @default.
• W2034656105 countsByYear W20346561052017 @default.
• W2034656105 countsByYear W20346561052020 @default.
• W2034656105 countsByYear W20346561052021 @default.
• W2034656105 countsByYear W20346561052022 @default.
• W2034656105 countsByYear W20346561052023 @default.
• W2034656105 crossrefType "journal-article" @default.
• W2034656105 hasAuthorship W2034656105A5013792120 @default.
• W2034656105 hasAuthorship W2034656105A5050182718 @default.
• W2034656105 hasAuthorship W2034656105A5053797819 @default.
• W2034656105 hasAuthorship W2034656105A5062228797 @default.
• W2034656105 hasAuthorship W2034656105A5063205640 @default.
• W2034656105 hasAuthorship W2034656105A5070749654 @default.
• W2034656105 hasAuthorship W2034656105A5071165719 @default.
• W2034656105 hasAuthorship W2034656105A5073028672 @default.
• W2034656105 hasAuthorship W2034656105A5075974674 @default.
• W2034656105 hasAuthorship W2034656105A5077566992 @default.
• W2034656105 hasAuthorship W2034656105A5080912506 @default.
• W2034656105 hasAuthorship W2034656105A5083222784 @default.
• W2034656105 hasConcept C104317684 @default.
• W2034656105 hasConcept C12387725 @default.
• W2034656105 hasConcept C126322002 @default.
• W2034656105 hasConcept C127716648 @default.
• W2034656105 hasConcept C134018914 @default.
• W2034656105 hasConcept C2781381752 @default.
• W2034656105 hasConcept C502942594 @default.
• W2034656105 hasConcept C54355233 @default.
• W2034656105 hasConcept C71924100 @default.
• W2034656105 hasConcept C86803240 @default.
• W2034656105 hasConcept C95444343 @default.
• W2034656105 hasConceptScore W2034656105C104317684 @default.
• W2034656105 hasConceptScore W2034656105C12387725 @default.
• W2034656105 hasConceptScore W2034656105C126322002 @default.
• W2034656105 hasConceptScore W2034656105C127716648 @default.
• W2034656105 hasConceptScore W2034656105C134018914 @default.
• W2034656105 hasConceptScore W2034656105C2781381752 @default.
• W2034656105 hasConceptScore W2034656105C502942594 @default.
• W2034656105 hasConceptScore W2034656105C54355233 @default.
• W2034656105 hasConceptScore W2034656105C71924100 @default.
• W2034656105 hasConceptScore W2034656105C86803240 @default.
• W2034656105 hasConceptScore W2034656105C95444343 @default.
• W2034656105 hasIssue "1" @default.
• W2034656105 hasLocation W20346561051 @default.
• W2034656105 hasLocation W20346561052 @default.
• W2034656105 hasOpenAccess W2034656105 @default.
• W2034656105 hasPrimaryLocation W20346561051 @default.
• W2034656105 hasRelatedWork W1977231502 @default.
• W2034656105 hasRelatedWork W1979689966 @default.

• next