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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034656760> ?p ?o ?g. }

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• W2034656760 abstract "The acute human immunodeficiency virus type 1 (HIV-1) infection of activated peripheral blood mononuclear cells (PBMCs) from normal donors results in inhibition of cell proliferation and generation of functional suppressive T cells. Cultured HIV-1 infected PBMCs but not uninfected PBMCs, following irradiation, can inhibit the proliferation of antigen-activated autologous T cells in a dose-dependent way. CD8+ cell subpopulation is responsible for this inhibition. The presence of anti-alpha interferon (IFN alpha) and anti-Tat antibodies in the culture medium counteracts the HIV-1-induced immunosuppression and prevents the generation of suppressive T cells by these PBMCs. The reported data should have major implications for strategies of AIDS treatment which, in association with antiviral drugs, aim at targetting immune disorders." @default.
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• W2034656760 date "1996-01-01" @default.
• W2034656760 modified "2023-10-06" @default.
• W2034656760 title "Repair of the in vitro HIV-1-induced immunosuppression and blockade of the generation of functional suppressive CD8 cells by anti-alpha interferon and anti-Tat antibodies" @default.
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• W2034656760 doi "https://doi.org/10.1016/0753-3322(96)85092-x" @default.
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