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- W2034657136 abstract "In order to characterize the behavioral effects produced by drug-induced changes in central dopamine neurotransmission, the behavior of mice was studied in a maze. The animals were given haloperidol (0.2 mg/kg, IP), apomorphine (0.1–3.2 mg/kg, IP), or solvent vehicle, during a 30- and 10-min time of preexposure to the maze, respectively, and their exploratory activity was recorded. The ability of these animals to find food in the same maze was later (+24 h) compared with the performance of a group not previously exposed to the maze (naive). In comparison with naive animals, untreated mice preexposed to the maze displayed a more efficient performance (latent learning) when trained to find food in the maze. It was found that haloperidol (0.2 mg/kg) or apomorphine (0.1–0.8 mg/kg) significantly suppressed the exploratory behavior of the animals during the time of preexposure. However, animals thus treated learned the maze 24 h later as rapidly as animals treated with solvent vehicle. Higher doses of apomorphine (1.6–3.2 mg/kg) also produced a suppression of exploratory behavior similar to that seen after its administration at lower doses, or after treatment with haloperidol; however, these animals did not display latent learning 24 h later." @default.
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- W2034657136 date "1977-09-01" @default.
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- W2034657136 title "Effects of apomorphine and haloperidol on exploratory behavior and latent learning in mice" @default.
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