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- W2034657982 abstract "Using in vitro hydroxyl radical-scavenging and quinone reductase-inducing assays, bioactivity-guided fractionation of an ethyl acetate-soluble extract of the fruits of the botanical dietary supplement, black chokeberry (Aronia melanocarpa), led to the isolation of 27 compounds, including a new depside, ethyl 2-[(3,4-dihydroxybenzoyloxy)-4,6-dihydroxyphenyl] acetate (1), along with 26 known compounds (2–27). The structures of the isolated compounds were identified by analysis of their physical and spectroscopic data ([α]D, NMR, IR, UV, and MS). Altogether, 17 compounds (1–4, 9, 15–17, and 19–27) showed significant antioxidant activity in the hydroxyl radical-scavenging assay, with hyperin (24, ED50 = 0.17 μM) being the most potent. The new compound (1, ED50 = 0.44 μM) also exhibited potent antioxidant activity in this assay. Three constituents of black chokeberry fruits doubled quinone reductase activity at concentrations <20 μM, namely, protocatechuic acid [9, concentration required to double quinone reductase activity (CD) = 4.3 μM], neochlorogenic acid methyl ester (22, CD = 6.7 μM), and quercetin (23, CD = 3.1 μM)." @default.
- W2034657982 created "2016-06-24" @default.
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- W2034657982 date "2012-11-13" @default.
- W2034657982 modified "2023-10-06" @default.
- W2034657982 title "Antioxidant and Quinone Reductase-Inducing Constituents of Black Chokeberry (Aronia melanocarpa) Fruits" @default.
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- W2034657982 doi "https://doi.org/10.1021/jf303712e" @default.
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