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• W2034658862 abstract "The fate of [ 14 C]glutamate and [ 14 C]aspartate in rat cerebral cortical slices was followed quantitatively by means of the previously described automatic scanning technique of paper radio-chromatograms, in the presence and absence of non-radiocative glucose, and in the case of [ 14 C]glutamate, also of the following non-radioactive tricarboxylic cycle acids: pyruvate, citrate, α-oxoglutarate, malate, oxalo-acetate and succinate. Both amino-acids were readily oxidized to CO 2 , glutamate increasing, aspartate not affecting the rate of endogenous oxygen uptake of the tissue. In addition the following metabolites accumulated: ( a ) From glutamate: aspartate, glutamine and γ -aminobutyrate, in order of decreasmg amounts. ( b ) From aspartate: glutamate, malate and citrate, in order of decreasmg amounts, with traces of glutamine, γ aminobutyrate and lactate. The presence of non-radioactive glucose as co-substrate caused the following effects. 1. On glutamate-.The total production of 14 CO 2 aswell as the oxygen uptake increased. This indicated that glucose oxidation had not replaced glutamate oxidation, but actually caused its stimulation. The conversion into glutamine was increased by a factor of 3, an effect similar to that caused by K + ions. The conversion into aspartate was decreased by a factor of 4. The accumulation of intracellular glutamate was much enhanced. 2. On aspartate: both 14 CO 2 production and oxygen uptake were stimulated, indicating that, as in the case of glutamate, glucose oxidation not only had not replaced the oxidation of amino-acid, but stimulated it. The production of glutamate, glutamine, γ -aminobutyrate and lactate was considerably increased while that of malate and citrate was unaffected. The following effects on glutamate metabolism were noted in the presence of non-radioactive tricarboxylic cycle acids: None of the acids affected 14 CO 2 production except α-oxoglutarate which caused a decrease of over half. This decrease was shown to be due to a dilution of [ 14 C]glutamate through equilibration with non-radioactive α-oxoglutarate; the latter acquired about half of the radioactivity of the [ 14 C]glutarnate added during the incubation. Pyruvate, like glucose, decreased the conversion to aspartate and increased glutamine formation, the latter, however, to a much lower degree than glucose. It also enhanced the accumulation of intracellular glutamate. Citrate, succinate, malate and oxaloacetate, particularly the latter two co-substrates, repressed the formation of [ 14 C]glutamine, but had no other effect on the pattern of distiibution of the metabolites formed from glutamate and on the permeability of this amino-acid into the cell." @default.
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• W2034658862 date "1962-07-31" @default.
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• W2034658862 title "The metabolism of glutamate and aspartate in rat cerebral cortical slices" @default.
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• W2034658862 doi "https://doi.org/10.1098/rspb.1962.0035" @default.
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