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- W2034662916 abstract "Although it is known that hypercarbia increases and benzodiazepines decrease cerebral blood flow (CBF), the effects of benzodiazepines on CBF responsiveness to CO 2 are not well documented. The influence on CBF and CBF-C0 2 sensitivity of placebo or midazolam, which is a new water-soluble benzodiazepine, was measured in eight healthy volunteers using the noninvasive 133 Xe inhalation method for CBF determination. Under normocarbia, midazolam decreased CBF from 40.6 ± 3.2 to 27.0 ± 5.0 ml 100 g −1 min −1 (x̄ ± SD). At a later session under hypercarbia, CBF was 58.8 ± 4.4 ml 100 g −1 min −1 after administration of placebo, and 49.1 ± 10.2 ml 100 g −1 min −1 after midazolam. The mean of the slopes correlating P a co 2 and CBF was significantly steeper with midazolam (2.5 ± 1.2 ml 100 g −1 min −1 mm Hg −1 ) than with placebo (1.5 ± 0.4 ml 100 g −1 min −1 mm Hg −1 ). Our results suggest that midazolam may be a safe agent to use in patients with intracranial hypertension, since it decreases CBF and thus cerebral blood volume; however, it should be administered with caution in nonventilated patients with increased intracranial pressure, since its beneficial effects on cerebrovascular tone can be readily counteracted by the increase in arterial CO 2 tension induced by this drug." @default.
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- W2034662916 date "1983-06-01" @default.
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- W2034662916 title "Effects of Midazolam on Cerebral Hemodynamics and Cerebral Vasomotor Responsiveness to Carbon Dioxide" @default.
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- W2034662916 doi "https://doi.org/10.1038/jcbfm.1983.33" @default.
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