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• W2034663238 abstract "Tretinoin (TRT) is a widely used retinoid for the topical treatment of acne, photo-aged skin, psoriasis and skin cancer which makes it a good candidate for topical formulation. Yet side effects, like redness, swelling, peeling, blistering and, erythema, in addition to its high lipophilicity make this challenging. Therefore, the aim of this study was the development of TRT-loaded proniosomes to improve the drug efficacy and to increase user acceptability and compliance by reducing its side effects. Nine formulae were prepared according to 32 factorial design and were evaluated for their morphology, vesicle size, entrapment efficiency (EE %), and% of drug released after 5 h. Hydrogel of the candidate formula, N8G (proniosomes prepared with 0.025% TRT, and Span60: cholesterol molar ratio of 3:1 and incorporated in 1% carbopol gel) was developed and evaluated for skin irritation test and clinical study in acne patients compared to marketed product. Candidate formula showed higher efficacy and very low irritation potential when compared to marketed product in human volunteers." @default.
• W2034663238 created "2016-06-24" @default.
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• W2034663238 date "2014-03-27" @default.
• W2034663238 modified "2023-10-17" @default.
• W2034663238 title "Formulation of tretinoin-loaded topical proniosomes for treatment of acne:<i>in-vitro</i>characterization, skin irritation test and comparative clinical study" @default.
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• W2034663238 doi "https://doi.org/10.3109/10717544.2014.896428" @default.
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