FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034665874> ?p ?o ?g. }

• W2034665874 endingPage "126" @default.
• W2034665874 startingPage "120" @default.
• W2034665874 abstract "<i>Background:</i> α-Interferon-2a (IFNα) alone is a therapy of limited proven benefit for non-uremic patients with chronic hepatitis C virus (HCV) infection. In dialyzed patients, such an effect is suggested on small short-term studies without sufficient clinical and virologic follow-up to document any sustained effect. <i>Protocol:</i> Twelve chronically hemodialyzed patients with chronic hepatitis C and waiting for renal transplantation were included in a prospective open study of treatment with IFNα. We used, as did others, doses of 3 million units (MU), three times a week, but for a longer period of treatment of 12 months. Follow-up was continued for 6 months after the end of IFNα in order to document any sustained biochemical, virological and histological responses. <i>Results:</i> Aminotransferase levels returned to the normal range within 1–2 months of treatment in all patients in whom they had been elevated at baseline. At 1 month of treatment, serum HCV-RNA was not detected in 5 (41%) patients and in 9 (75%) at 12 months. A sustained virological response was documented in 4 (33%) patients 6 months after the end of treatment. Relapse occurred in 5 patients within 2 months after IFNα withdrawal. HCV genotype was not predictive of any sustained response. At inclusion, using the histologic Metavir scoring system, half of the patients had low-grade cytolytic activity and none had cirrhosis. After IFNα, liver biopsy specimens were available from 9 patients and showed histologic improvement in 3. IFNα tolerance was poor, inducing a 5% mean weight loss and the acute rejection of two nonfunctioning kidney grafts. <i>Conclusion:</i> This study documents that administration of IFNα at 3 MU three times a week, for 12 months, in hemodialysis patients with chronic hepatitis C was efficient for clearing the serum of HCV-RNA in 75% of the patients. A sustained response was maintained in one third of these patients after cessation of IFNα, and was predicted by the early serum clearance of the virus within the first 2 months of treatment. We confirm that a 12-month treatment period carries a higher sustained response rate than shorter treatment periods. These encouraging results call for larger studies in uremic patients, using IFNα alone or in association with new antiviral drugs." @default.
• W2034665874 created "2016-06-24" @default.
• W2034665874 creator A5003707751 @default.
• W2034665874 creator A5015005652 @default.
• W2034665874 creator A5024475307 @default.
• W2034665874 creator A5042697514 @default.
• W2034665874 creator A5064923067 @default.
• W2034665874 creator A5079364269 @default.
• W2034665874 creator A5088029443 @default.
• W2034665874 creator A5088169515 @default.
• W2034665874 creator A5088916021 @default.
• W2034665874 date "2001-01-01" @default.
• W2034665874 modified "2023-10-17" @default.
• W2034665874 title "Virological and Histological Responses to One Year Alpha-Interferon-2a in Hemodialyzed Patients with Chronic Hepatitis C" @default.
• W2034665874 cites W2318639814 @default.
• W2034665874 cites W4242105639 @default.
• W2034665874 cites W4247482913 @default.
• W2034665874 doi "https://doi.org/10.1159/000045971" @default.
• W2034665874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11399913" @default.
• W2034665874 hasPublicationYear "2001" @default.
• W2034665874 type Work @default.
• W2034665874 sameAs 2034665874 @default.
• W2034665874 citedByCount "46" @default.
• W2034665874 countsByYear W20346658742012 @default.
• W2034665874 countsByYear W20346658742013 @default.
• W2034665874 countsByYear W20346658742014 @default.
• W2034665874 countsByYear W20346658742016 @default.
• W2034665874 crossrefType "journal-article" @default.
• W2034665874 hasAuthorship W2034665874A5003707751 @default.
• W2034665874 hasAuthorship W2034665874A5015005652 @default.
• W2034665874 hasAuthorship W2034665874A5024475307 @default.
• W2034665874 hasAuthorship W2034665874A5042697514 @default.
• W2034665874 hasAuthorship W2034665874A5064923067 @default.
• W2034665874 hasAuthorship W2034665874A5079364269 @default.
• W2034665874 hasAuthorship W2034665874A5088029443 @default.
• W2034665874 hasAuthorship W2034665874A5088169515 @default.
• W2034665874 hasAuthorship W2034665874A5088916021 @default.
• W2034665874 hasConcept C126322002 @default.
• W2034665874 hasConcept C203014093 @default.
• W2034665874 hasConcept C2522874641 @default.
• W2034665874 hasConcept C2775934546 @default.
• W2034665874 hasConcept C2776178377 @default.
• W2034665874 hasConcept C2776408679 @default.
• W2034665874 hasConcept C2776455275 @default.
• W2034665874 hasConcept C2777214474 @default.
• W2034665874 hasConcept C2777766500 @default.
• W2034665874 hasConcept C2781228144 @default.
• W2034665874 hasConcept C2909179924 @default.
• W2034665874 hasConcept C71924100 @default.
• W2034665874 hasConcept C90924648 @default.
• W2034665874 hasConceptScore W2034665874C126322002 @default.
• W2034665874 hasConceptScore W2034665874C203014093 @default.
• W2034665874 hasConceptScore W2034665874C2522874641 @default.
• W2034665874 hasConceptScore W2034665874C2775934546 @default.
• W2034665874 hasConceptScore W2034665874C2776178377 @default.
• W2034665874 hasConceptScore W2034665874C2776408679 @default.
• W2034665874 hasConceptScore W2034665874C2776455275 @default.
• W2034665874 hasConceptScore W2034665874C2777214474 @default.
• W2034665874 hasConceptScore W2034665874C2777766500 @default.
• W2034665874 hasConceptScore W2034665874C2781228144 @default.
• W2034665874 hasConceptScore W2034665874C2909179924 @default.
• W2034665874 hasConceptScore W2034665874C71924100 @default.
• W2034665874 hasConceptScore W2034665874C90924648 @default.
• W2034665874 hasIssue "2" @default.
• W2034665874 hasLocation W20346658741 @default.
• W2034665874 hasLocation W20346658742 @default.
• W2034665874 hasOpenAccess W2034665874 @default.
• W2034665874 hasPrimaryLocation W20346658741 @default.
• W2034665874 hasRelatedWork W118298973 @default.
• W2034665874 hasRelatedWork W1550484024 @default.
• W2034665874 hasRelatedWork W2006454743 @default.
• W2034665874 hasRelatedWork W2012818923 @default.
• W2034665874 hasRelatedWork W2013851368 @default.
• W2034665874 hasRelatedWork W2045862714 @default.
• W2034665874 hasRelatedWork W2067435274 @default.
• W2034665874 hasRelatedWork W2105082770 @default.
• W2034665874 hasRelatedWork W2414025728 @default.
• W2034665874 hasRelatedWork W3665843 @default.
• W2034665874 hasVolume "88" @default.
• W2034665874 isParatext "false" @default.
• W2034665874 isRetracted "false" @default.
• W2034665874 magId "2034665874" @default.
• W2034665874 workType "article" @default.