FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034668199> ?p ?o ?g. }

• W2034668199 endingPage "45" @default.
• W2034668199 startingPage "39" @default.
• W2034668199 abstract "Oxygen free radical generation may have important secondary damaging effects after the onset of cerebral ischemia. Free radical scavengers have been used successfully in attenuating neuronal damage in the reperfusion period in transient forebrain ischemia. There are limited data on effectiveness in models of focal ischemia. Two free radical scavengers, alpha-phenyl-n-tert-butyl-nitrone (PBN) and N-tert-butyl-(2-sulfophenyl)-nitrone (S-PBN), have been shown to reduce oxidative-stress-induced neuronal injury. Whereas PBN has been demonstrated to reduce infarct volume in focal ischemia, neuroprotection has not been evaluated with S-PBN. The present study was designed to evaluate the neuroprotective effect of PBN and S-PBN compared to vehicle in a focal embolic middle cerebral artery (MCA) cerebral ischemia model in rats. Wistar rats were randomly divided into three groups (n = 10 each group). Animals in the control group received vehicle and those in the treatment groups were treated with PBN or S-PBN (both 100 mg/kg/day x 3 days, intraperitoneally) starting 2 h after the introduction of an autologous thrombus into the right-side MCA. The neurological outcome was observed and compared before and after treatment and between groups. The percentage of cerebral infarct volume was estimated from 2,3, 5-triphenyltetrazolium chloride stained coronal slices 72 h after the ischemic insult. Two-hour postischemia administration of PBN or S-PBN significantly improved neurobehavioral scores at 24 h following MCA embolization (both P < 0.01). The percentage of infarct volume for animals receiving vehicle was 32.8 +/- 9.4%. Two-hour delayed administration of PBN and S-PBN achieved a 35.4% reduction in infarct volume in treatment groups when compared with animals receiving vehicle (PBN vs control, 21.2 +/- 10.9% vs 32.8 +/- 9.4%; P < 0.05; S-PBN vs control, 21.2 +/- 13.1%, (P < 0.05). These data indicate that free radical generation may be involved in brain damage in this model and 2-h delayed postischemia treatment with PBN and S-PBN may have neuroprotective effects in focal cerebral ischemia. As S-PBN does not normally cross the blood-brain barrier, the neuroprotection evident in this study may be explained by entry into the brain via damaged vessels." @default.
• W2034668199 created "2016-06-24" @default.
• W2034668199 creator A5042946501 @default.
• W2034668199 creator A5050507154 @default.
• W2034668199 creator A5078898153 @default.
• W2034668199 date "2000-05-01" @default.
• W2034668199 modified "2023-10-14" @default.
• W2034668199 title "Neuroprotection by 2-h Postischemia Administration of Two Free Radical Scavengers, α-phenyl-n-tert-butyl-nitrone (PBN) and N-tert-butyl-(2-sulfophenyl)-nitrone (S-PBN), in Rats Subjected to Focal Embolic Cerebral Ischemia" @default.
• W2034668199 cites W1911312547 @default.
• W2034668199 cites W1977149656 @default.
• W2034668199 cites W1979470828 @default.
• W2034668199 cites W1979522883 @default.
• W2034668199 cites W1983224810 @default.
• W2034668199 cites W1984907601 @default.
• W2034668199 cites W1985788035 @default.
• W2034668199 cites W1993027064 @default.
• W2034668199 cites W1998669119 @default.
• W2034668199 cites W1998878708 @default.
• W2034668199 cites W2000484187 @default.
• W2034668199 cites W2008421055 @default.
• W2034668199 cites W2009967691 @default.
• W2034668199 cites W2015268116 @default.
• W2034668199 cites W2016293448 @default.
• W2034668199 cites W2016517081 @default.
• W2034668199 cites W2019470361 @default.
• W2034668199 cites W2022788768 @default.
• W2034668199 cites W2023105087 @default.
• W2034668199 cites W2023760934 @default.
• W2034668199 cites W2027317604 @default.
• W2034668199 cites W2030704464 @default.
• W2034668199 cites W2033573399 @default.
• W2034668199 cites W2033706377 @default.
• W2034668199 cites W2040685668 @default.
• W2034668199 cites W2044824361 @default.
• W2034668199 cites W2047852028 @default.
• W2034668199 cites W2049189117 @default.
• W2034668199 cites W2065264404 @default.
• W2034668199 cites W2069250827 @default.
• W2034668199 cites W2080630228 @default.
• W2034668199 cites W2085935168 @default.
• W2034668199 cites W2092171478 @default.
• W2034668199 cites W2095450169 @default.
• W2034668199 cites W2133451731 @default.
• W2034668199 cites W2149326995 @default.
• W2034668199 cites W32893265 @default.
• W2034668199 cites W4295736448 @default.
• W2034668199 doi "https://doi.org/10.1006/exnr.2000.7364" @default.
• W2034668199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10785442" @default.
• W2034668199 hasPublicationYear "2000" @default.
• W2034668199 type Work @default.
• W2034668199 sameAs 2034668199 @default.
• W2034668199 citedByCount "62" @default.
• W2034668199 countsByYear W20346681992012 @default.
• W2034668199 countsByYear W20346681992013 @default.
• W2034668199 countsByYear W20346681992015 @default.
• W2034668199 countsByYear W20346681992017 @default.
• W2034668199 countsByYear W20346681992018 @default.
• W2034668199 countsByYear W20346681992019 @default.
• W2034668199 crossrefType "journal-article" @default.
• W2034668199 hasAuthorship W2034668199A5042946501 @default.
• W2034668199 hasAuthorship W2034668199A5050507154 @default.
• W2034668199 hasAuthorship W2034668199A5078898153 @default.
• W2034668199 hasConcept C126322002 @default.
• W2034668199 hasConcept C141071460 @default.
• W2034668199 hasConcept C161790260 @default.
• W2034668199 hasConcept C185592680 @default.
• W2034668199 hasConcept C25498285 @default.
• W2034668199 hasConcept C2775841333 @default.
• W2034668199 hasConcept C2776035437 @default.
• W2034668199 hasConcept C2779440280 @default.
• W2034668199 hasConcept C2779664164 @default.
• W2034668199 hasConcept C42219234 @default.
• W2034668199 hasConcept C541997718 @default.
• W2034668199 hasConcept C55493867 @default.
• W2034668199 hasConcept C71924100 @default.
• W2034668199 hasConcept C98274493 @default.
• W2034668199 hasConceptScore W2034668199C126322002 @default.
• W2034668199 hasConceptScore W2034668199C141071460 @default.
• W2034668199 hasConceptScore W2034668199C161790260 @default.
• W2034668199 hasConceptScore W2034668199C185592680 @default.
• W2034668199 hasConceptScore W2034668199C25498285 @default.
• W2034668199 hasConceptScore W2034668199C2775841333 @default.
• W2034668199 hasConceptScore W2034668199C2776035437 @default.
• W2034668199 hasConceptScore W2034668199C2779440280 @default.
• W2034668199 hasConceptScore W2034668199C2779664164 @default.
• W2034668199 hasConceptScore W2034668199C42219234 @default.
• W2034668199 hasConceptScore W2034668199C541997718 @default.
• W2034668199 hasConceptScore W2034668199C55493867 @default.
• W2034668199 hasConceptScore W2034668199C71924100 @default.
• W2034668199 hasConceptScore W2034668199C98274493 @default.
• W2034668199 hasIssue "1" @default.
• W2034668199 hasLocation W20346681991 @default.
• W2034668199 hasLocation W20346681992 @default.
• W2034668199 hasOpenAccess W2034668199 @default.
• W2034668199 hasPrimaryLocation W20346681991 @default.
• W2034668199 hasRelatedWork W1965348397 @default.
• W2034668199 hasRelatedWork W2033768819 @default.
• W2034668199 hasRelatedWork W2077655479 @default.

• next