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• W2034668581 startingPage "e11247" @default.
• W2034668581 abstract "MAPK-activated protein kinase 2 (MK2), a direct substrate of p38 MAPK, plays key roles in multiple physiological functions in mitosis. Here, we show for the first time the unique distribution pattern of MK2 in meiosis. Phospho-MK2 was localized on bipolar spindle minus ends and along the interstitial axes of homologous chromosomes extending over centromere regions and arm regions at metaphase of first meiosis (MI stage) in mouse oocytes. At metaphase of second meiosis (MII stage), p-MK2 was localized on the bipolar spindle minus ends and at the inner centromere region of sister chromatids as dots. Knockdown or inhibition of MK2 resulted in spindle defects. Spindles were surrounded by irregular nondisjunction chromosomes, which were arranged in an amphitelic or syntelic/monotelic manner, or chromosomes detached from the spindles. Kinetochore-microtubule attachments were impaired in MK2-deficient oocytes because spindle microtubules became unstable in response to cold treatment. In addition, homologous chromosome segregation and meiosis progression were inhibited in these oocytes. Our data suggest that MK2 may be essential for functional meiotic bipolar spindle formation, chromosome segregation and proper kinetochore-microtubule attachments." @default.
• W2034668581 created "2016-06-24" @default.
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• W2034668581 date "2010-06-28" @default.
• W2034668581 modified "2023-09-26" @default.
• W2034668581 title "MAPK-Activated Protein Kinase 2 Is Required for Mouse Meiotic Spindle Assembly and Kinetochore-Microtubule Attachment" @default.
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• W2034668581 cites W1966478901 @default.
• W2034668581 cites W1979308791 @default.
• W2034668581 cites W1982090173 @default.
• W2034668581 cites W1993079403 @default.
• W2034668581 cites W1999849989 @default.
• W2034668581 cites W2005842596 @default.
• W2034668581 cites W2014101291 @default.
• W2034668581 cites W2016479508 @default.
• W2034668581 cites W2024261622 @default.
• W2034668581 cites W2032325024 @default.
• W2034668581 cites W2032497688 @default.
• W2034668581 cites W2033548259 @default.
• W2034668581 cites W2034184306 @default.
• W2034668581 cites W2037607661 @default.
• W2034668581 cites W2040562682 @default.
• W2034668581 cites W2040727271 @default.
• W2034668581 cites W2042605812 @default.
• W2034668581 cites W2046089519 @default.
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• W2034668581 cites W2056354464 @default.
• W2034668581 cites W2056681619 @default.
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• W2034668581 cites W2067486558 @default.
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• W2034668581 cites W2075351483 @default.
• W2034668581 cites W2076606495 @default.
• W2034668581 cites W2078142614 @default.
• W2034668581 cites W2078493328 @default.
• W2034668581 cites W2080280371 @default.
• W2034668581 cites W2081130105 @default.
• W2034668581 cites W2081406767 @default.
• W2034668581 cites W2083016975 @default.
• W2034668581 cites W2084598669 @default.
• W2034668581 cites W2085190855 @default.
• W2034668581 cites W2086655427 @default.
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• W2034668581 cites W2097846668 @default.
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• W2034668581 cites W2101497044 @default.
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• W2034668581 cites W2115943316 @default.
• W2034668581 cites W2120785595 @default.
• W2034668581 cites W2121083656 @default.
• W2034668581 cites W2127264152 @default.
• W2034668581 cites W2133503471 @default.
• W2034668581 cites W2137346595 @default.
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• W2034668581 doi "https://doi.org/10.1371/journal.pone.0011247" @default.
• W2034668581 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2893158" @default.
• W2034668581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20596525" @default.
• W2034668581 hasPublicationYear "2010" @default.
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