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- W2034668720 abstract "To the Editor.— Matsuoka et al 1 wrote approvingly of cetylpyridinium chloride (CPC) as a glycosaminoglycan (GAG) fixative in histologic sections, confirming other opinions quoted in their letter to the editor recently published in theArchives. Whatever the practical advantages of CPC (and they are clearly real), I would like to sound a strong cautionary note. I introduced CPC in 1955 as a precipitant for polyanions, including GAGs (see Scott 2 for a review), and shortly thereafter it was used in histology by Williams and Jackson 3 as a fixative, usually together with formaldehyde, and, equally significantly, as a blocker of uptake of cationic dyes by Geyer. 4 In the latter role, the organic cation occupies the binding sites that cationic dyes would occupy in staining the substrate. The blockade is stable and permanent; it cannot be reversed by, for example, simple washing with water. The blockade could be made" @default.
- W2034668720 created "2016-06-24" @default.
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- W2034668720 date "1989-07-01" @default.
- W2034668720 modified "2023-09-25" @default.
- W2034668720 title "Cetylpyridinium Chloride as a Fixative for Glycosaminoglycans in Histologic Sections" @default.
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- W2034668720 doi "https://doi.org/10.1001/archderm.1989.01670190136025" @default.
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