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- W2034670037 abstract "A somatostatin analog, [D-Ala5, D-Trp8]-somatostatin, has been found to selectively inhibit insulin and GH release in rats. The release of these hormones is inhibited by an analog dose of 5 microgram/kg in short term experiments (15 min from analog administration to blood sampling), while glucagon levels are not lowered by analog doses as high as 500 microgram/kg. The lowered insulin to glucagon ratio results in hyperglycemia. [D-Ala5, D-Trp8]Somatostatin is also long acting; a 1 mg/kg dose results in hypoinsulinemia for 2 h and hyperglycemia for 3 h." @default.
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- W2034670037 date "1978-07-01" @default.
- W2034670037 modified "2023-09-25" @default.
- W2034670037 title "Prolonged Suppression of Insulin Release by a Somatostatin Analog" @default.
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- W2034670037 doi "https://doi.org/10.1210/endo-103-1-81" @default.
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