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- W2034670108 abstract "Class B G protein-coupled receptors (GPCRs) are important drug targets in many human diseases, including type 2 diabetes, obesity, cardiovascular disease and neurodegeneration. Peptide hormones bind to these receptors through interactions with both the extracellular domain and transmembrane domain. Despite remarkable advances in structural studies of GPCRs, structural characterization of the full-length class B receptors remains extremely challenging due to their conformational complexity. The recently solved structures of class B GPCRs reveal the structural basis of peptide ligand recognition and modulation mechanisms of small molecule allosteric modulators. Furthermore, these structures provide essential insights into molecular mechanisms of class B GPCR signal transduction and modulation." @default.
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- W2034670108 date "2008-10-01" @default.
- W2034670108 modified "2023-10-05" @default.
- W2034670108 title "Using SSRS marker biotechnology to analyze genetic variability in five populations of sea cucumber from China, Russia, South Korea and Japan" @default.
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- W2034670108 doi "https://doi.org/10.1016/j.jbiotec.2008.07.146" @default.
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