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• W2034671146 startingPage "213" @default.
• W2034671146 abstract "Previously, it was determined that the presence of rVPr1 (a recombinant Pimpla hypochondriaca venom protein), in the haemocoel of two lepidopteran larvae, significantly increases their susceptibility to the biological control agents (BCAs), Bacillus thuringiensis (Bt) and Beauveria bassiana (Richards and Dani, 2010; Richards et al., 2011). The current work examines the mechanism of action of rVPr1 and demonstrates that it binds to the surface of some haemocytes and disrupts the organization of the haemocyte cytoskeleton. This binding is associated with a reduction in the ability of haemocytes to extend pseudopods, and to move and form aggregates in vitro over an 18 h period. Moreover, rVPr1 exerts these effects after a relatively short incubation period (1.5 h) and the haemocytes do not recover their ability to form aggregates after rVPr1 has been removed. In addition, rVPr1 significantly reduces haemocyte-mediated phagocytosis of Bt and B. bassiana in vitro (p < 0.05) and, following injection into the insect haemocoel, rVPr1 reduces the number of circulating haemocytes per ml of haemolymph (this being significantly different to the controls 3 h after injection [p = 0.05]). The finding that rVPr1 has an adverse effect on haemocyte function and number in vivo, supports the hypothesis that this wasp protein significantly increases the susceptibility of lepidopteran larvae to Bt and B. bassiana, by suppressing haemocyte-mediated immune responses in the insects which otherwise would be directed against these BCAs." @default.
• W2034671146 created "2016-06-24" @default.
• W2034671146 creator A5041452887 @default.
• W2034671146 creator A5042532691 @default.
• W2034671146 creator A5045958172 @default.
• W2034671146 date "2013-02-01" @default.
• W2034671146 modified "2023-10-13" @default.
• W2034671146 title "Immunosuppressive properties of a protein (rVPr1) from the venom of the endoparasitic wasp, Pimpla hypochondriaca: Mechanism of action and potential use for improving biological control strategies" @default.
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• W2034671146 doi "https://doi.org/10.1016/j.jinsphys.2012.06.001" @default.
• W2034671146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22698823" @default.
• W2034671146 hasPublicationYear "2013" @default.
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