FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034671296> ?p ?o ?g. }

• W2034671296 abstract "Sulfs are extracellular endosulfatases that selectively remove the 6-O-sulfate groups from cell surface heparan sulfate (HS) chain. By altering the sulfation at these particular sites, Sulfs function to remodel HS chains. As a result of the remodeling activity, HSulf2 regulates a multitude of cell-signaling events that depend on interactions between proteins and HS. Previous efforts to characterize the substrate specificity of human Sulfs (HSulfs) focused on the analysis of HS disaccharides and synthetic repeating units. In this study, we characterized the substrate preferences of human HSulf2 using HS oligosaccharides with various lengths and sulfation degrees from several naturally occurring HS sources by applying liquid chromatography mass spectrometry based glycomics methods. The results showed that HSulf2 preferentially digests highly sulfated HS oligosaccharides with zero acetyl groups and this preference is length dependent. In terms of length of oligosaccharides, HSulf2 digestion induced more sulfation decrease on DP6 (DP: degree of polymerization) compared to DP2, DP4 and DP8. In addition, the HSulf2 preferentially digests the oligosaccharide domain located at the non-reducing end (NRE) of the HS and heparin chain. In addition, the HSulf2 digestion products were altered only for specific isomers. HSulf2 treated NRE oligosaccharides also showed greater decrease in cell proliferation than those from internal domains of the HS chain. After further chromatographic separation, we identified the three most preferred unsaturated hexasaccharide for HSulf2." @default.
• W2034671296 created "2016-06-24" @default.
• W2034671296 creator A5048117106 @default.
• W2034671296 creator A5051318955 @default.
• W2034671296 creator A5051506148 @default.
• W2034671296 creator A5052848702 @default.
• W2034671296 creator A5074638151 @default.
• W2034671296 date "2014-08-15" @default.
• W2034671296 modified "2023-09-24" @default.
• W2034671296 title "Oligosaccharide Substrate Preferences of Human Extracellular Sulfatase Sulf2 Using Liquid Chromatography-Mass Spectrometry Based Glycomics Approaches" @default.
• W2034671296 cites W1972236015 @default.
• W2034671296 cites W1974638654 @default.
• W2034671296 cites W1975510007 @default.
• W2034671296 cites W1976981044 @default.
• W2034671296 cites W1978405139 @default.
• W2034671296 cites W1978904916 @default.
• W2034671296 cites W1979745217 @default.
• W2034671296 cites W1988069810 @default.
• W2034671296 cites W1990306679 @default.
• W2034671296 cites W1993847445 @default.
• W2034671296 cites W1996795546 @default.
• W2034671296 cites W1996821824 @default.
• W2034671296 cites W2002163811 @default.
• W2034671296 cites W2009934212 @default.
• W2034671296 cites W2013623858 @default.
• W2034671296 cites W2017071197 @default.
• W2034671296 cites W2019777638 @default.
• W2034671296 cites W2022836663 @default.
• W2034671296 cites W2028938330 @default.
• W2034671296 cites W2029085074 @default.
• W2034671296 cites W2032257487 @default.
• W2034671296 cites W2040353416 @default.
• W2034671296 cites W2045630388 @default.
• W2034671296 cites W2046778129 @default.
• W2034671296 cites W2048358455 @default.
• W2034671296 cites W2052217119 @default.
• W2034671296 cites W2053206569 @default.
• W2034671296 cites W2060441535 @default.
• W2034671296 cites W2064292429 @default.
• W2034671296 cites W2066847170 @default.
• W2034671296 cites W2073170672 @default.
• W2034671296 cites W2074580060 @default.
• W2034671296 cites W2076566152 @default.
• W2034671296 cites W2078325464 @default.
• W2034671296 cites W2082621603 @default.
• W2034671296 cites W2082754441 @default.
• W2034671296 cites W2089450737 @default.
• W2034671296 cites W2089587787 @default.
• W2034671296 cites W2091113651 @default.
• W2034671296 cites W2096942445 @default.
• W2034671296 cites W2099481674 @default.
• W2034671296 cites W2108326699 @default.
• W2034671296 cites W2117845045 @default.
• W2034671296 cites W2133025277 @default.
• W2034671296 cites W2139445236 @default.
• W2034671296 cites W2154427247 @default.
• W2034671296 cites W2159416047 @default.
• W2034671296 cites W2162137259 @default.
• W2034671296 cites W2167400776 @default.
• W2034671296 cites W2167544720 @default.
• W2034671296 cites W2169829977 @default.
• W2034671296 doi "https://doi.org/10.1371/journal.pone.0105143" @default.
• W2034671296 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4134258" @default.
• W2034671296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25127119" @default.
• W2034671296 hasPublicationYear "2014" @default.
• W2034671296 type Work @default.
• W2034671296 sameAs 2034671296 @default.
• W2034671296 citedByCount "3" @default.
• W2034671296 countsByYear W20346712962019 @default.
• W2034671296 countsByYear W20346712962020 @default.
• W2034671296 crossrefType "journal-article" @default.
• W2034671296 hasAuthorship W2034671296A5048117106 @default.
• W2034671296 hasAuthorship W2034671296A5051318955 @default.
• W2034671296 hasAuthorship W2034671296A5051506148 @default.
• W2034671296 hasAuthorship W2034671296A5052848702 @default.
• W2034671296 hasAuthorship W2034671296A5074638151 @default.
• W2034671296 hasBestOaLocation W20346712961 @default.
• W2034671296 hasConcept C106686826 @default.
• W2034671296 hasConcept C108625454 @default.
• W2034671296 hasConcept C1491633281 @default.
• W2034671296 hasConcept C155138218 @default.
• W2034671296 hasConcept C162356407 @default.
• W2034671296 hasConcept C185592680 @default.
• W2034671296 hasConcept C18903297 @default.
• W2034671296 hasConcept C206212055 @default.
• W2034671296 hasConcept C2777289219 @default.
• W2034671296 hasConcept C2777726330 @default.
• W2034671296 hasConcept C2778041096 @default.
• W2034671296 hasConcept C43617362 @default.
• W2034671296 hasConcept C55493867 @default.
• W2034671296 hasConcept C86803240 @default.
• W2034671296 hasConceptScore W2034671296C106686826 @default.
• W2034671296 hasConceptScore W2034671296C108625454 @default.
• W2034671296 hasConceptScore W2034671296C1491633281 @default.
• W2034671296 hasConceptScore W2034671296C155138218 @default.
• W2034671296 hasConceptScore W2034671296C162356407 @default.
• W2034671296 hasConceptScore W2034671296C185592680 @default.
• W2034671296 hasConceptScore W2034671296C18903297 @default.
• W2034671296 hasConceptScore W2034671296C206212055 @default.
• W2034671296 hasConceptScore W2034671296C2777289219 @default.

• next