FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034671678> ?p ?o ?g. }

• W2034671678 endingPage "291" @default.
• W2034671678 startingPage "279" @default.
• W2034671678 abstract "An increasing body of evidence indicates that the vitamin A metabolite retinoic acid (RA) plays a role in adult brain plasticity by activating gene transcription through nuclear receptors. Our previous studies in mice have shown that a moderate downregulation of retinoid-mediated transcription contributed to aging-related deficits in hippocampal long-term potentiation and long-term declarative memory (LTDM). Here, knock-out, pharmacological, and nutritional approaches were used in a series of radial-arm maze experiments with mice to further assess the hypothesis that retinoid-mediated nuclear events are causally involved in preferential degradation of hippocampal function in aging. Molecular and behavioral findings confirmed our hypothesis. First, a lifelong vitamin A supplementation, like short-term RA administration, was shown to counteract the aging-related hippocampal (but not striatal) hypoexpression of a plasticity-related retinoid target-gene, GAP43 (reverse transcription-PCR analyses, experiment 1), as well as short-term/working memory (STWM) deterioration seen particularly in organization demanding trials (STWM task, experiment 2). Second, using a two-stage paradigm of LTDM, we demonstrated that the vitamin A supplementation normalized memory encoding-induced recruitment of (hippocampo-prefrontal) declarative memory circuits, without affecting (striatal) procedural memory system activity in aged mice (Fos neuroimaging, experiment 3A) and alleviated their LTDM impairment (experiment 3B). Finally, we showed that (knock-out, experiment 4) RA receptor beta and retinoid X receptor gamma, known to be involved in STWM (Wietrzych et al., 2005), are also required for LTDM. Hence, aging-related retinoid signaling hypoexpression disrupts hippocampal cellular properties critically required for STWM organization and LTDM formation, and nutritional vitamin A supplementation represents a preventive strategy. These findings are discussed within current neurobiological perspectives questioning the historical consensus on STWM and LTDM system partition." @default.
• W2034671678 created "2016-06-24" @default.
• W2034671678 creator A5024417875 @default.
• W2034671678 creator A5029891848 @default.
• W2034671678 creator A5033904738 @default.
• W2034671678 creator A5041600727 @default.
• W2034671678 creator A5059777541 @default.
• W2034671678 creator A5062869789 @default.
• W2034671678 creator A5067673882 @default.
• W2034671678 creator A5072598102 @default.
• W2034671678 creator A5078462648 @default.
• W2034671678 creator A5086939449 @default.
• W2034671678 creator A5087020824 @default.
• W2034671678 date "2008-01-02" @default.
• W2034671678 modified "2023-10-16" @default.
• W2034671678 title "Retinoid Hyposignaling Contributes to Aging-Related Decline in Hippocampal Function in Short-Term/Working Memory Organization and Long-Term Declarative Memory Encoding in Mice" @default.
• W2034671678 cites W1527976882 @default.
• W2034671678 cites W1543878663 @default.
• W2034671678 cites W1564211606 @default.
• W2034671678 cites W1603889731 @default.
• W2034671678 cites W187277792 @default.
• W2034671678 cites W1944496442 @default.
• W2034671678 cites W1966225158 @default.
• W2034671678 cites W1966316797 @default.
• W2034671678 cites W1966711088 @default.
• W2034671678 cites W1970878854 @default.
• W2034671678 cites W1972375217 @default.
• W2034671678 cites W1973976256 @default.
• W2034671678 cites W1976405146 @default.
• W2034671678 cites W1977381980 @default.
• W2034671678 cites W1984091130 @default.
• W2034671678 cites W1985783408 @default.
• W2034671678 cites W1987040411 @default.
• W2034671678 cites W1993921528 @default.
• W2034671678 cites W1999170657 @default.
• W2034671678 cites W2000465559 @default.
• W2034671678 cites W2001461663 @default.
• W2034671678 cites W2012793421 @default.
• W2034671678 cites W2014821825 @default.
• W2034671678 cites W2016298359 @default.
• W2034671678 cites W2016898344 @default.
• W2034671678 cites W2019326141 @default.
• W2034671678 cites W2019928465 @default.
• W2034671678 cites W2020463330 @default.
• W2034671678 cites W2021330953 @default.
• W2034671678 cites W2024822097 @default.
• W2034671678 cites W2025631499 @default.
• W2034671678 cites W2028318252 @default.
• W2034671678 cites W2030703067 @default.
• W2034671678 cites W2031418608 @default.
• W2034671678 cites W2032724628 @default.
• W2034671678 cites W2035261316 @default.
• W2034671678 cites W2045604089 @default.
• W2034671678 cites W2067732057 @default.
• W2034671678 cites W2068978877 @default.
• W2034671678 cites W2069776467 @default.
• W2034671678 cites W2070575950 @default.
• W2034671678 cites W2071175430 @default.
• W2034671678 cites W2075069104 @default.
• W2034671678 cites W2082198643 @default.
• W2034671678 cites W2087592242 @default.
• W2034671678 cites W2088167686 @default.
• W2034671678 cites W2090990109 @default.
• W2034671678 cites W2096547256 @default.
• W2034671678 cites W2101387411 @default.
• W2034671678 cites W2105268524 @default.
• W2034671678 cites W2106489915 @default.
• W2034671678 cites W2110264624 @default.
• W2034671678 cites W2114987540 @default.
• W2034671678 cites W2119137992 @default.
• W2034671678 cites W2121588049 @default.
• W2034671678 cites W2125577585 @default.
• W2034671678 cites W2128318174 @default.
• W2034671678 cites W2150185446 @default.
• W2034671678 cites W2166113206 @default.
• W2034671678 cites W2324794108 @default.
• W2034671678 cites W2613217394 @default.
• W2034671678 cites W4240553276 @default.
• W2034671678 cites W4245679009 @default.
• W2034671678 doi "https://doi.org/10.1523/jneurosci.4065-07.2008" @default.
• W2034671678 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6671152" @default.
• W2034671678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18171945" @default.
• W2034671678 hasPublicationYear "2008" @default.
• W2034671678 type Work @default.
• W2034671678 sameAs 2034671678 @default.
• W2034671678 citedByCount "88" @default.
• W2034671678 countsByYear W20346716782012 @default.
• W2034671678 countsByYear W20346716782013 @default.
• W2034671678 countsByYear W20346716782014 @default.
• W2034671678 countsByYear W20346716782015 @default.
• W2034671678 countsByYear W20346716782016 @default.
• W2034671678 countsByYear W20346716782017 @default.
• W2034671678 countsByYear W20346716782018 @default.
• W2034671678 countsByYear W20346716782019 @default.
• W2034671678 countsByYear W20346716782020 @default.
• W2034671678 countsByYear W20346716782021 @default.
• W2034671678 countsByYear W20346716782022 @default.
• W2034671678 countsByYear W20346716782023 @default.

• next