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- W2034671935 endingPage "e99628" @default.
- W2034671935 startingPage "e99628" @default.
- W2034671935 abstract "The CD44+ and CD44− subpopulations of the colorectal cancer cell line Caco2 were analyzed separately for their sensitivities to the antitumor drug camptothecin. CD44+ cells were less sensitive to camptothecin than CD44− cells. The relative resistance of CD44+ cells was correlated with (i) reduced activity of the nuclear enzyme topoisomerase I and (ii) insensitivity of this enzyme to camptothecin when analyzed in extracts. In contrast, topoisomerase I activity was higher in extracts from CD44− cells and the enzyme was camptothecin sensitive. Topoisomerase I from the two subpopulations were differentially phosphorylated in a manner that appeared to determine the drug sensitivity and activity of the enzyme. This finding was further supported by the fact that phosphorylation of topoisomerase I in CD44+ cell extract by protein kinase CK2 converted the enzyme to a camptothecin sensitive, more active form mimicking topoisomerase I in extracts from CD44− cells. Conversely, dephosphorylation of topoisomerase I in extracts from CD44− cells rendered the enzyme less active and camptothecin resistant. These findings add to our understanding of chemotherapy resistance in the Caco2 CD44+ cancer stem cell model." @default.
- W2034671935 created "2016-06-24" @default.
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- W2034671935 date "2014-06-24" @default.
- W2034671935 modified "2023-09-27" @default.
- W2034671935 title "Decreased Camptothecin Sensitivity of the Stem-Cell-Like Fraction of Caco2 Cells Correlates with an Altered Phosphorylation Pattern of Topoisomerase I" @default.
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- W2034671935 cites W1969762229 @default.
- W2034671935 cites W1978770961 @default.
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- W2034671935 cites W2168083201 @default.
- W2034671935 cites W226502161 @default.
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- W2034671935 doi "https://doi.org/10.1371/journal.pone.0099628" @default.
- W2034671935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4069021" @default.
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