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- W2034672740 abstract "Summary.1The fibrinogen concentration has been estimated to 0.28, 0.30, 0.56 g per 100 ml in dog, horse, and ox plasma respectively.2The different reactivities to thrombin of various plasma species have been confirmed. The reactivity decreased in the following order: dog, human, ox, and horse plasma.3The difference in reactivity of the plasmas was least at optimal pH, and increased with increasing pH.4The addition of optimal amounts of calcium did not significantly alter the proportional differences among the plasmas.5When bovine thrombin was used, the quantitative differences in reactivity were as follows: dog 125, human 100, ox 93, and horse 65 per cent.6Purified fibrinogens from the same species showed the same reactivity pattern as plasmas, but dog fibrinogen showed a proportionally greater activity than dog plasma.7Thrombin was found to be species specific. Except in human plasma and in human fibrinogen, dog thrombin was more active than the homologous thrombins. With this exception, the thrombins preferred the homologous plasma or fibrinogen.8The thrombin specificity was especially pronounced with dog thrombin. A dog thrombin estimated to be 1 T. U. in human plasma or fibrinogen amounted to 2.2 and 4.1 T. U. as estimated on the corresponding dog materials.9On the basis of these findings the author recommends that the use of thrombin units be replaced by clotting times under standardized conditions in scientific work." @default.
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- W2034672740 date "1957-04-01" @default.
- W2034672740 modified "2023-09-27" @default.
- W2034672740 title "Species Differences of Clotting Factors in Ox, Dog, Horse, and Man. Thrombin and Fibrinogen." @default.
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- W2034672740 doi "https://doi.org/10.1111/j.1748-1716.1957.tb01486.x" @default.
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