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- W2034673963 abstract "The known sequences of HIV-1 viruses have been categorized into subtypes based on the phylogenetic partitioning of their env and gag gene sequences. The env gene encodes the protein gp120, which contains five sequence- variable regions (V1 to V5), of which the V3 loop is of central importance to viral infectivity. The V3 loop consensus sequences of HIV-1 subtype A and C viruses are similar, and more similar to one another than the V3 consensus sequences of any other two HIV-1 subtypes. However, using a position-specific statistical comparison, we found that the V3 region of these two subtypes is statistically distinct (p = ∼0.0). (The p-value calculated to the lowest limit of representation on the computer used to run the calculation. This lowest limit was 10−16. Although theoretically a p-value cannot be equal to 0.0, the p-value for the comparisons in question can be intuitively considered to be extremely small, or ∼0.0.)" @default.
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- W2034673963 date "2006-07-01" @default.
- W2034673963 modified "2023-10-14" @default.
- W2034673963 title "Distinct Sequence Patterns Characterize the V3 Region of HIV Type 1 gp120 from Subtypes A and C" @default.
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- W2034673963 doi "https://doi.org/10.1089/aid.2006.22.703" @default.
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