FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034674760> ?p ?o ?g. }

• W2034674760 endingPage "1367" @default.
• W2034674760 startingPage "1355" @default.
• W2034674760 abstract "There is growing interest in the potential beneficial effects of flavonoids in the aging and diseased brain. We have investigated the potential of the flavanone hesperetin and two of its metabolites, hesperetin-7-O-β-d-glucuronide and 5-nitro-hesperetin, to inhibit oxidative stress-induced neuronal apoptosis. Exposure of cortical neurons to hydrogen peroxide led to the activation of apoptosis signal-regulating kinase 1 via its de-phosphorylation at Ser963, the phosphorylation of c-jun N-terminal kinase and c-Jun (Ser73) and the activation of caspase 3 and caspase 9. Whilst hesperetin glucuronide failed to exert protection, both hesperetin and 5-nitro-hesperetin were effective at preventing neuronal apoptosis via a mechanism involving the activation/phosphorylation of both Akt/protein kinase B and extracellular signal-regulated kinase 1 and 2 (ERK1/2). Protection against oxidative injury and the activation of Akt and ERK1/2 followed a bell-shaped response and was most apparent at 100 nmol/L concentrations. The activation of ERK1/2 and Akt by flavanones led to the inhibition of the pro-apoptotic proteins, apoptosis signal-regulating kinase 1, by phosphorylation at Ser83 and Bad, by phosphorylation at both Ser136 and Ser112 and to the inhibition of peroxide-induced caspase 9 and caspase 3 activation. Thus, flavanones may protect neurons against oxidative insults via the modulation of neuronal apoptotic machinery." @default.
• W2034674760 created "2016-06-24" @default.
• W2034674760 creator A5006797104 @default.
• W2034674760 creator A5009786597 @default.
• W2034674760 creator A5034492572 @default.
• W2034674760 creator A5045749402 @default.
• W2034674760 creator A5081513258 @default.
• W2034674760 date "2007-11-01" @default.
• W2034674760 modified "2023-10-18" @default.
• W2034674760 title "Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons" @default.
• W2034674760 cites W1529396499 @default.
• W2034674760 cites W1536581914 @default.
• W2034674760 cites W1564588342 @default.
• W2034674760 cites W1791888878 @default.
• W2034674760 cites W1824652155 @default.
• W2034674760 cites W1840931106 @default.
• W2034674760 cites W1914622032 @default.
• W2034674760 cites W1966259921 @default.
• W2034674760 cites W1969419810 @default.
• W2034674760 cites W1971135597 @default.
• W2034674760 cites W1971442892 @default.
• W2034674760 cites W1976062660 @default.
• W2034674760 cites W1976441097 @default.
• W2034674760 cites W1981331199 @default.
• W2034674760 cites W1984547206 @default.
• W2034674760 cites W1984933247 @default.
• W2034674760 cites W1986463236 @default.
• W2034674760 cites W1990297868 @default.
• W2034674760 cites W1994583461 @default.
• W2034674760 cites W2001276434 @default.
• W2034674760 cites W2008750119 @default.
• W2034674760 cites W2008872627 @default.
• W2034674760 cites W2009118106 @default.
• W2034674760 cites W2015004507 @default.
• W2034674760 cites W2020124177 @default.
• W2034674760 cites W2026789068 @default.
• W2034674760 cites W2026824792 @default.
• W2034674760 cites W2030573603 @default.
• W2034674760 cites W2034580062 @default.
• W2034674760 cites W2036501947 @default.
• W2034674760 cites W2057713336 @default.
• W2034674760 cites W2060479161 @default.
• W2034674760 cites W2061482527 @default.
• W2034674760 cites W2061853325 @default.
• W2034674760 cites W2064194276 @default.
• W2034674760 cites W2069897341 @default.
• W2034674760 cites W2073101340 @default.
• W2034674760 cites W2078166953 @default.
• W2034674760 cites W2081705668 @default.
• W2034674760 cites W2085042044 @default.
• W2034674760 cites W2086255122 @default.
• W2034674760 cites W2093628776 @default.
• W2034674760 cites W2097767970 @default.
• W2034674760 cites W2097820520 @default.
• W2034674760 cites W2099821002 @default.
• W2034674760 cites W2107614388 @default.
• W2034674760 cites W2112535458 @default.
• W2034674760 cites W2122896910 @default.
• W2034674760 cites W2122947129 @default.
• W2034674760 cites W2123619341 @default.
• W2034674760 cites W2128960139 @default.
• W2034674760 cites W2145903555 @default.
• W2034674760 cites W2147114673 @default.
• W2034674760 cites W2147309521 @default.
• W2034674760 cites W2155832294 @default.
• W2034674760 cites W2159068216 @default.
• W2034674760 cites W2170891211 @default.
• W2034674760 cites W4234012592 @default.
• W2034674760 cites W4240628861 @default.
• W2034674760 cites W4247242273 @default.
• W2034674760 cites W4253975284 @default.
• W2034674760 doi "https://doi.org/10.1111/j.1471-4159.2007.04841.x" @default.
• W2034674760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17961201" @default.
• W2034674760 hasPublicationYear "2007" @default.
• W2034674760 type Work @default.
• W2034674760 sameAs 2034674760 @default.
• W2034674760 citedByCount "229" @default.
• W2034674760 countsByYear W20346747602012 @default.
• W2034674760 countsByYear W20346747602013 @default.
• W2034674760 countsByYear W20346747602014 @default.
• W2034674760 countsByYear W20346747602015 @default.
• W2034674760 countsByYear W20346747602016 @default.
• W2034674760 countsByYear W20346747602017 @default.
• W2034674760 countsByYear W20346747602018 @default.
• W2034674760 countsByYear W20346747602019 @default.
• W2034674760 countsByYear W20346747602020 @default.
• W2034674760 countsByYear W20346747602021 @default.
• W2034674760 countsByYear W20346747602022 @default.
• W2034674760 countsByYear W20346747602023 @default.
• W2034674760 crossrefType "journal-article" @default.
• W2034674760 hasAuthorship W2034674760A5006797104 @default.
• W2034674760 hasAuthorship W2034674760A5009786597 @default.
• W2034674760 hasAuthorship W2034674760A5034492572 @default.
• W2034674760 hasAuthorship W2034674760A5045749402 @default.
• W2034674760 hasAuthorship W2034674760A5081513258 @default.
• W2034674760 hasConcept C11960822 @default.
• W2034674760 hasConcept C184235292 @default.
• W2034674760 hasConcept C185592680 @default.

• next